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A Study on Effect of Electroacupuncture on Gene Expression in Hypothalamus of Rats with Stress-Induced Prehypertension Based on Gene Chip Technology
المؤلفون المشاركون
Guo, Yan
Xie, Xiaojia
Liu, Qingguo
Wang, Zhaoyang
Guo, Changqing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
To explore the effect of electroacupuncture (EA) on gene expression in the hypothalamus of rats with stress-induced prehypertension and try to reveal its biological mechanism with gene chip technology.
Methods.
The stress-induced hypertensive rat model was prepared by combining electric foot-shocks with generated noise.
Molding cycle lasted for 14 days and EA intervention was applied on model + EA group during model preparation.
Rat Gene 2.0 Array technology was used for the determination of gene expression profiles and the screened key genes were verified by real-time fluorescence quantitative PCR method.
Results.
Compared with the blank group, 234 genes were upregulated and 73 were downregulated in the model group.
Compared with the model group, 110 genes were upregulated and 273 genes were downregulated in model + EA group.
The PCR results of the key genes including HSPB1, P2RX4, PPP1R14A, and TH are consistent with that of gene chip test.
Conclusion.
EA could significantly lower blood pressure of stress-induced prehypertension rats and affect its gene expression profile in hypothalamus.
Genes and their signal transduction pathway that related to the contraction of vascular smooth muscle, concentration of Ca2+, and excitability of sympathetic nerve may be involved in EA’s antihypertensive mechanism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Xiaojia& Guo, Yan& Liu, Qingguo& Wang, Zhaoyang& Guo, Changqing. 2015. A Study on Effect of Electroacupuncture on Gene Expression in Hypothalamus of Rats with Stress-Induced Prehypertension Based on Gene Chip Technology. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063394
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Xiaojia…[et al.]. A Study on Effect of Electroacupuncture on Gene Expression in Hypothalamus of Rats with Stress-Induced Prehypertension Based on Gene Chip Technology. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063394
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Xiaojia& Guo, Yan& Liu, Qingguo& Wang, Zhaoyang& Guo, Changqing. A Study on Effect of Electroacupuncture on Gene Expression in Hypothalamus of Rats with Stress-Induced Prehypertension Based on Gene Chip Technology. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063394
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063394
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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