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Antifungal Properties of Crude Extracts, Fractions, and Purified Compounds from Bark of Curatella americana L. (Dilleniaceae) against Candida Species
المؤلفون المشاركون
Ueda-Nakamura, Tânia
Mendes de Toledo, Cleyton Eduardo
Santos, Patrícia Regina
Nakamura, Celso Vataru
Palazzo de Mello, João Carlos
Dias Filho, Benedito Prado
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The ethnomedicinal plant Curatella americana L.
(Dilleniaceae) is a common shrub in the Brazilian cerrado, in which crude extract showed antifungal activity in a preliminary study.
In this work, the antifungal and cytotoxic properties of the crude extract, fractions, and isolated compounds from C.
americana were evaluated against the standard yeast strains Candida albicans, C.
tropicalis, and C.
parapsilosis, clinical isolates, and fluconazole-resistant strains.
The combinatory effects between subfractions and isolated compounds and effects on cell morphology, virulence factors, and exogenous ergosterol were also evaluated.
The MIC obtained against the Candida species including fluconazole-resistant strain ranged from 15.3 to 31.3 µg/mL for crude extract, 3.9 to 15.6 µg/mL for ethyl acetate fraction, and 7.8 to 31.3 µg/mL for subfractions.
The isolated compounds identified as 4′-O-methyl-catechin, epicatechin-3-O-gallate, and 4′-O-methyl-catechin-3-O-gallate showed lower antifungal activity than the crude extract and fractions (MIC ranging from 31.3 to 125.0 µg/mL).
The addition of exogenous ergosterol to yeast culture did not interfere in the antifungal activity of the extract and its fractions.
Synergistic antifungal activity was observed between subfractions and isolated compounds.
The effects on virulence factors and the different mechanisms of action compared to fluconazole and nystatin suggest that this ethnomedicinal plant may be an effective alternative treatment for candidiasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mendes de Toledo, Cleyton Eduardo& Santos, Patrícia Regina& Palazzo de Mello, João Carlos& Dias Filho, Benedito Prado& Nakamura, Celso Vataru& Ueda-Nakamura, Tânia. 2015. Antifungal Properties of Crude Extracts, Fractions, and Purified Compounds from Bark of Curatella americana L. (Dilleniaceae) against Candida Species. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063449
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mendes de Toledo, Cleyton Eduardo…[et al.]. Antifungal Properties of Crude Extracts, Fractions, and Purified Compounds from Bark of Curatella americana L. (Dilleniaceae) against Candida Species. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063449
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mendes de Toledo, Cleyton Eduardo& Santos, Patrícia Regina& Palazzo de Mello, João Carlos& Dias Filho, Benedito Prado& Nakamura, Celso Vataru& Ueda-Nakamura, Tânia. Antifungal Properties of Crude Extracts, Fractions, and Purified Compounds from Bark of Curatella americana L. (Dilleniaceae) against Candida Species. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063449
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063449
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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