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Effects of Soothing Liver and Invigorating Spleen Recipes on the IKK β -NF- κ B Signaling Pathway in Kupffer Cells of Nonalcoholic Steatohepatitis Rats
المؤلفون المشاركون
Yang, Qin-He
Xu, Yong-Jian
Gong, Xiang-Wen
Liang, Yin-Ji
Zhang, Yu-Pei
Wang, Guan-Long
Li, Yuan-Yuan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This study investigates the effect of soothing liver and invigorating spleen recipes on steatohepatitis examining the IKKβ-NF-κB signaling pathway in KCs of NASH rats.
SD male rats were randomly divided into 8 groups, and the NASH model was induced by a high-fat diet (HFD).
After 26 weeks, liver tissue was examined in H&E stained sections and liver function was monitored biochemically.
KCs were isolated by Seglen’s method, with some modifications.
The mRNA and protein expression of the IKKβ-NF-κB signaling pathway components was examined by quantitative PCR and Western blotting.
The results show that the high-fat diet induced NASH in the rats, and the soothing liver recipe and invigorating spleen recipe decreased the levels of TNF-α, IL-1, and IL-6 in KCs, as well as inhibiting the mRNA and protein expression of the IKKβ-NF-κB signaling pathway components.
In conclusion, the experiment indicated the importance of the IKKβ-NF-κB signaling pathway in KCs for the anti-inflammatory effects of the soothing liver and invigorating spleen recipes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gong, Xiang-Wen& Xu, Yong-Jian& Yang, Qin-He& Liang, Yin-Ji& Zhang, Yu-Pei& Wang, Guan-Long…[et al.]. 2015. Effects of Soothing Liver and Invigorating Spleen Recipes on the IKK β -NF- κ B Signaling Pathway in Kupffer Cells of Nonalcoholic Steatohepatitis Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063465
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gong, Xiang-Wen…[et al.]. Effects of Soothing Liver and Invigorating Spleen Recipes on the IKK β -NF- κ B Signaling Pathway in Kupffer Cells of Nonalcoholic Steatohepatitis Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063465
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gong, Xiang-Wen& Xu, Yong-Jian& Yang, Qin-He& Liang, Yin-Ji& Zhang, Yu-Pei& Wang, Guan-Long…[et al.]. Effects of Soothing Liver and Invigorating Spleen Recipes on the IKK β -NF- κ B Signaling Pathway in Kupffer Cells of Nonalcoholic Steatohepatitis Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063465
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063465
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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