Protective Effects of Aqueous Extract of Luehea divaricata against Behavioral and Oxidative Changes Induced by 3-Nitropropionic Acid in Rats
المؤلفون المشاركون
Soares, Félix A. A.
Boligon, Aline Augusti
Courtes, Aline Alves
Arantes, Letícia Priscila
Barcelos, Rômulo Pillon
da Silva, Ingrid Kich
Puntel, Robson
Athayde, Margareth Linde
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease.
Accordingly, 3-nitropropionic acid (3-NP) has been found to effectively produce HD-like symptoms.
Luehea divaricata (L.
divaricata), popularly known in Brazil as “açoita-cavalo,” may act as a neuroprotective agent in vitro and in vivo.
We evaluated the hypothesis that the aqueous extract of L.
divaricata could prevent behavioral and oxidative alterations induced by 3-NP in rats.
25 adult Wistar male rats were divided into 5 groups: (1) control, (2) L.
divaricata (1000 mg/kg), (3) 3-NP, (4) L.
divaricata (500 mg/kg) + 3-NP, and (5) L.
divaricata (1000 mg/kg) + 3-NP.
Groups 2, 4, and 5 received L.
divaricata via intragastric gavage daily for 10 days.
Animals in groups 3, 4, and 5 received 20 mg/kg 3-NP daily from days 8–10.
At day 10, parameters of locomotor activity and biochemical evaluations were performed.
Indeed, rats treated with 3-NP showed decreased locomotor activity compared to controls.
Additionally, 3-NP increased levels of reactive oxygen species and lipid peroxidation and decreased ratio of GSH/GSSG and acetylcholinesterase activity in cortex and/or striatum.
Our results suggest that rats pretreated with L.
divaricata prior to 3-NP treatment showed neuroprotective effects when compared to 3-NP treated controls, which may be due to its antioxidant properties.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Courtes, Aline Alves& Arantes, Letícia Priscila& Barcelos, Rômulo Pillon& da Silva, Ingrid Kich& Boligon, Aline Augusti& Athayde, Margareth Linde…[et al.]. 2015. Protective Effects of Aqueous Extract of Luehea divaricata against Behavioral and Oxidative Changes Induced by 3-Nitropropionic Acid in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063497
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Courtes, Aline Alves…[et al.]. Protective Effects of Aqueous Extract of Luehea divaricata against Behavioral and Oxidative Changes Induced by 3-Nitropropionic Acid in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063497
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Courtes, Aline Alves& Arantes, Letícia Priscila& Barcelos, Rômulo Pillon& da Silva, Ingrid Kich& Boligon, Aline Augusti& Athayde, Margareth Linde…[et al.]. Protective Effects of Aqueous Extract of Luehea divaricata against Behavioral and Oxidative Changes Induced by 3-Nitropropionic Acid in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063497
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063497
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر