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Hypocholesterolemic and Antiatherosclerotic Potential of Basella alba Leaf Extract in Hypercholesterolemia-Induced Rabbits
المؤلفون المشاركون
Shukor, Mohd Yunus
Azlan, Azrina
Ahmad, Siti Aqlima
Gunasekaran, Baskaran
Salvamani, Shamala
Yeap, Swee Keong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Hypercholesterolemia is the major risk factor that leads to atherosclerosis.
Nowadays, alternative treatment using medicinal plants gained much attention since the usage of statins leads to adverse health effects, especially liver and muscle toxicity.
This study was designed to investigate the hypocholesterolemic and antiatherosclerotic effects of Basella alba (B.
alba) using hypercholesterolemia-induced rabbits.
Twenty New Zealand white rabbits were divided into 5 groups and fed with varying diets: normal diet, 2% high cholesterol diet (HCD), 2% HCD + 10 mg/kg simvastatin, 2% HCD + 100 mg/kg B.
alba extract, and 2% HCD + 200 mg/kg B.
alba extract, respectively.
The treatment with B.
alba extract significantly lowered the levels of total cholesterol, LDL, and triglycerides and increased HDL and antioxidant enzymes (SOD and GPx) levels.
The elevated levels of liver enzymes (AST and ALT) and creatine kinase were noted in hypercholesterolemic and statin treated groups indicating liver and muscle injuries.
Treatment with B.
alba extract also significantly suppressed the aortic plaque formation and reduced the intima: media ratio as observed in simvastatin-treated group.
This is the first in vivo study on B.
alba that suggests its potential as an alternative therapeutic agent for hypercholesterolemia and atherosclerosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gunasekaran, Baskaran& Salvamani, Shamala& Azlan, Azrina& Ahmad, Siti Aqlima& Yeap, Swee Keong& Shukor, Mohd Yunus. 2015. Hypocholesterolemic and Antiatherosclerotic Potential of Basella alba Leaf Extract in Hypercholesterolemia-Induced Rabbits. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063553
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gunasekaran, Baskaran…[et al.]. Hypocholesterolemic and Antiatherosclerotic Potential of Basella alba Leaf Extract in Hypercholesterolemia-Induced Rabbits. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063553
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gunasekaran, Baskaran& Salvamani, Shamala& Azlan, Azrina& Ahmad, Siti Aqlima& Yeap, Swee Keong& Shukor, Mohd Yunus. Hypocholesterolemic and Antiatherosclerotic Potential of Basella alba Leaf Extract in Hypercholesterolemia-Induced Rabbits. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063553
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063553
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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