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Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Asmawi, Mohd Zaini
Yam, Mun Fei
Fung Ang, Lee
Ahmad, Mariam
Mohamed, Elsnoussi Ali
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
In the present study, a 50% ethanolic extract of Orthosiphon stamineus was tested for its α-glucosidase inhibitory activity.
In vivo assays of the extract (containing 1.02%, 3.76%, and 3.03% of 3′hydroxy-5,6,7,4′-tetramethoxyflavone, sinensetin, and eupatorin, resp.) showed that it possessed an inhibitory activity against α-glucosidase in normal rats loaded with starch and sucrose.
The results showed that 1000 mg/kg of the 50% ethanolic extract of O.
stamineus significantly ( P < 0.05 ) decreased the plasma glucose levels of the experimental animals in a manner resembling the effect of acarbose.
In streptozotocin-induced diabetic rats, only the group treated with 1000 mg/kg of the extract showed significantly ( P < 0.05 ) lower plasma glucose levels after starch loading.
Hence, α-glucosidase inhibition might be one of the mechanisms by which O.
stamineus extract exerts its antidiabetic effect.
Furthermore, our findings indicated that the 50% ethanolic extract of O.
stamineus can be considered as a potential agent for the management of diabetes mellitus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohamed, Elsnoussi Ali& Ahmad, Mariam& Fung Ang, Lee& Asmawi, Mohd Zaini& Yam, Mun Fei. 2015. Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063563
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohamed, Elsnoussi Ali…[et al.]. Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063563
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohamed, Elsnoussi Ali& Ahmad, Mariam& Fung Ang, Lee& Asmawi, Mohd Zaini& Yam, Mun Fei. Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063563
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063563
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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