Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Asmawi, Mohd Zaini
Yam, Mun Fei
Fung Ang, Lee
Ahmad, Mariam
Mohamed, Elsnoussi Ali
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
In the present study, a 50% ethanolic extract of Orthosiphon stamineus was tested for its α-glucosidase inhibitory activity.
In vivo assays of the extract (containing 1.02%, 3.76%, and 3.03% of 3′hydroxy-5,6,7,4′-tetramethoxyflavone, sinensetin, and eupatorin, resp.) showed that it possessed an inhibitory activity against α-glucosidase in normal rats loaded with starch and sucrose.
The results showed that 1000 mg/kg of the 50% ethanolic extract of O.
stamineus significantly ( P < 0.05 ) decreased the plasma glucose levels of the experimental animals in a manner resembling the effect of acarbose.
In streptozotocin-induced diabetic rats, only the group treated with 1000 mg/kg of the extract showed significantly ( P < 0.05 ) lower plasma glucose levels after starch loading.
Hence, α-glucosidase inhibition might be one of the mechanisms by which O.
stamineus extract exerts its antidiabetic effect.
Furthermore, our findings indicated that the 50% ethanolic extract of O.
stamineus can be considered as a potential agent for the management of diabetes mellitus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohamed, Elsnoussi Ali& Ahmad, Mariam& Fung Ang, Lee& Asmawi, Mohd Zaini& Yam, Mun Fei. 2015. Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063563
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohamed, Elsnoussi Ali…[et al.]. Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063563
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohamed, Elsnoussi Ali& Ahmad, Mariam& Fung Ang, Lee& Asmawi, Mohd Zaini& Yam, Mun Fei. Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063563
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063563
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر