Overcome Cancer Cell Drug Resistance Using Natural Products

المؤلفون المشاركون

Wang, Pu
Yang, Hua Li
Yang, Ying Juan
Wang, Lan
Lee, Shao Chin

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-09-01

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الطب البشري

الملخص EN

Chemotherapy is one of the major treatment methods for cancer.

However, failure in chemotherapy is not uncommon, mainly due to dose-limiting toxicity associated with drug resistance.

Management of drug resistance is important towards successful chemotherapy.

There are many reports in the Chinese literature that natural products can overcome cancer cell drug resistance, which deserve sharing with scientific and industrial communities.

We summarized the reports into four categories: (1) in vitro studies using cell line models; (2) serum pharmacology; (3) in vivo studies using animal models; and (4) clinical studies.

Fourteen single compounds were reported to have antidrug resistance activity for the first time.

In vitro, compounds were able to overcome drug resistance at nontoxic or subtoxic concentrations, in a dose-dependent manner, by inhibiting drug transporters, cell detoxification capacity, or cell apoptosis sensitivity.

Studies in vivo showed that single compounds, herbal extract, and formulas had potent antidrug resistance activities.

Importantly, many single compounds, herbal extracts, and formulas have been used clinically to treat various diseases including cancer.

The review provides comprehensive data on use of natural compounds to overcome cancer cell drug resistance in China, which may facilitate the therapeutic development of natural products for clinical management of cancer drug resistance.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Pu& Yang, Hua Li& Yang, Ying Juan& Wang, Lan& Lee, Shao Chin. 2015. Overcome Cancer Cell Drug Resistance Using Natural Products. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1063580

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Pu…[et al.]. Overcome Cancer Cell Drug Resistance Using Natural Products. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1063580

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Pu& Yang, Hua Li& Yang, Ying Juan& Wang, Lan& Lee, Shao Chin. Overcome Cancer Cell Drug Resistance Using Natural Products. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1063580

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1063580