Effect of Keishibukuryogan on Genetic and Dietary Obesity Models
المؤلفون المشاركون
Tsuneyama, Koichi
Hayakawa, Yoshihiro
Saiki, Ikuo
Gao, Fengying
Yokoyama, Satoru
Shimada, Yutaka
Fujimoto, Makoto
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Obesity has been recognized as one of the most important risk factors for a variety of chronic diseases, such as diabetes, hypertension/cardiovascular diseases, steatosis/hepatitis, and cancer.
Keishibukuryogan (KBG, Gui Zhi Fu Ling Wan in Chinese) is a traditional Chinese/Japanese (Kampo) medicine that has been known to improve blood circulation and is also known for its anti-inflammatory or scavenging effect.
In this study, we evaluated the effect of KBG in two distinct rodent models of obesity driven by either a genetic (SHR/NDmcr-cp rat model) or dietary (high-fat diet-induced mouse obesity model) mechanism.
Although there was no significant effect on the body composition in either the SHR rat or the DIO mouse models, KBG treatment significantly decreased the serum level of leptin and liver TG level in the DIO mouse, but not in the SHR rat model.
Furthermore, a lower fat deposition in liver and a smaller size of adipocytes in white adipose tissue were observed in the DIO mice treated with KBG.
Importantly, we further found downregulation of genes involved in lipid metabolism in the KBG-treated liver, along with decreased liver TG and cholesterol level.
Our present data experimentally support in fact that KBG can be an attractive Kampo medicine to improve obese status through a regulation of systemic leptin level and/or lipid metabolism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Fengying& Yokoyama, Satoru& Fujimoto, Makoto& Tsuneyama, Koichi& Saiki, Ikuo& Shimada, Yutaka…[et al.]. 2015. Effect of Keishibukuryogan on Genetic and Dietary Obesity Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063606
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Fengying…[et al.]. Effect of Keishibukuryogan on Genetic and Dietary Obesity Models. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063606
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Fengying& Yokoyama, Satoru& Fujimoto, Makoto& Tsuneyama, Koichi& Saiki, Ikuo& Shimada, Yutaka…[et al.]. Effect of Keishibukuryogan on Genetic and Dietary Obesity Models. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063606
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063606
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر