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Metabolic Interaction of the Active Constituents of Coptis chinensis in Human Liver Microsomes
المؤلفون المشاركون
Liu, Songcan
Jiang, Jian
Zhu, Leilei
Miao, Ping
Shen, Shujiao
Zhang, Xinfeng
Zeng, Jin
Qiu, Fu-rong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-06
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Coptis chinensis is commonly used in traditional Chinese medicine.
The study investigated metabolic interaction of the active constituents (berberine, coptisine, palmatine, and jatrorrhizine) of Coptis chinensis in human liver microsomes.
After incubation of the four constituents of Coptis chinensis in HLMs, the metabolism of the four constituents was observed by HPLC.
The in vitro inhibition experiment between the active constituents was conducted, and IC50 value was estimated.
Coptisine exhibited inhibitions against the formation of the two metabolites of berberine with IC50 values of 6.5 and 8.3 μM, respectively.
Palmatine and jatrorrhizine showed the weaker inhibitory effect on the formation of the metabolites of berberine.
Berberine showed a weak inhibitory effect on the production of coptisine metabolite with an IC50 value of 115 μM, and palmatine and jatrorrhizine had little inhibitory effect on the formation of coptisine metabolite.
Berberine, coptisine, and jatrorrhizine showed no inhibitory effect on the generation of palmatine metabolite (IC50 > 200 μM).
The findings suggested that there are different degrees of metabolic interaction between the four components.
Coptisine showed the strongest inhibition toward berberine metabolism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Songcan& Zhang, Xinfeng& Qiu, Fu-rong& Miao, Ping& Shen, Shujiao& Zhu, Leilei…[et al.]. 2015. Metabolic Interaction of the Active Constituents of Coptis chinensis in Human Liver Microsomes. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1063611
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Songcan…[et al.]. Metabolic Interaction of the Active Constituents of Coptis chinensis in Human Liver Microsomes. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1063611
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Songcan& Zhang, Xinfeng& Qiu, Fu-rong& Miao, Ping& Shen, Shujiao& Zhu, Leilei…[et al.]. Metabolic Interaction of the Active Constituents of Coptis chinensis in Human Liver Microsomes. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1063611
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063611
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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