The Protective Effects of Curcumin on Obesity-Related Glomerulopathy Are Associated with Inhibition of Wntβ-Catenin Signaling Activation in Podocytes
المؤلفون المشاركون
Liu, Bao-li
Chen, Yi-pu
Cheng, Hong
Wang, Yan-yan
Rui, Hong-liang
Yang, Min
Dong, Hong-rui
Han, Dan-nuo
Dong, Jing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The present study investigated the effects of curcumin, one of the most important active ingredients of turmeric, on podocyte injury in vitro and obesity-related glomerulopathy (ORG) in vivo.
Cellular experiments in vitro showed that curcumin significantly antagonized leptin-induced downregulation of the mRNA and protein expression of podocyte-associated molecules including nephrin, podocin, podoplanin, and podocalyxin.
Animal experiments in vivo showed that curcumin significantly reduced the body weight, Lee’s index, abdominal fat index, urinary protein excretion, and average glomerular diameter and significantly upregulated the mRNA and protein expressions of the above podocyte-associated molecules in ORG mice.
Furthermore, the experiments in vitro and in vivo both displayed that curcumin could downregulate the mRNA and protein expressions of Wnt1, Wnt2b, Wnt6, and β-catenin and upregulate the phosphorylation level of β-catenin protein in podocytes and renal tissue.
In conclusion, curcumin is able to alleviate the harmful reaction of leptin on podocytes and reduce the severity of ORG.
The above protective effects are associated with the inhibition of Wnt/β-catenin signaling activation in podocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Bao-li& Chen, Yi-pu& Cheng, Hong& Wang, Yan-yan& Rui, Hong-liang& Yang, Min…[et al.]. 2015. The Protective Effects of Curcumin on Obesity-Related Glomerulopathy Are Associated with Inhibition of Wntβ-Catenin Signaling Activation in Podocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063658
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Bao-li…[et al.]. The Protective Effects of Curcumin on Obesity-Related Glomerulopathy Are Associated with Inhibition of Wntβ-Catenin Signaling Activation in Podocytes. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063658
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Bao-li& Chen, Yi-pu& Cheng, Hong& Wang, Yan-yan& Rui, Hong-liang& Yang, Min…[et al.]. The Protective Effects of Curcumin on Obesity-Related Glomerulopathy Are Associated with Inhibition of Wntβ-Catenin Signaling Activation in Podocytes. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063658
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063658
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر