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Rikkunshito Ameliorates Cancer Cachexia Partly through Elevation of Glucarate in Plasma
المؤلفون المشاركون
Inui, Akio
Ohbuchi, Katsuya
Yoshida, Masaru
Nishiumi, Shin
Fujitsuka, Naoki
Hattori, Tomohisa
Yamamoto, Masahiro
Azuma, Takeshi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Cancer cachexia, which is characterized by decreased food intake, weight loss and systemic inflammation, increases patient’s morbidity and mortality.
We previously showed that rikkunshito (RKT), a Japanese traditional herbal medicine (Kampo), ameliorated the symptoms of cancer cachexia through ghrelin signaling-dependent and independent pathways.
To investigate other mechanisms of RKT action in cancer cachexia, we performed metabolome analysis of plasma in a rat model bearing the Yoshida AH-130 hepatoma.
A total of 110 metabolites were detected in plasma and RKT treatment significantly altered levels of 23 of those metabolites in cachexia model rats.
Among them, glucarate, which is known to have anticarcinogenic activity through detoxification of carcinogens via inhibition of β -glucuronidase, was increased in plasma following administration of RKT.
In our AH-130 ascites-induced cachexia rat model, administration of glucarate delayed onset of weight loss, improved muscle atrophy, and reduced ascites content.
Additionally, glucarate reduced levels of plasma interferon- γ (IFN- γ ) in tumor-bearing rats and was also found to suppress LPS-induced IFN- γ expression in splenocytes in vitro.
These results suggest that glucarate has anti-inflammatory activity via a direct effect on immune host cells and suggest that RKT may also ameliorate inflammation partly through the elevation of glucarate in plasma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ohbuchi, Katsuya& Nishiumi, Shin& Fujitsuka, Naoki& Hattori, Tomohisa& Yamamoto, Masahiro& Inui, Akio…[et al.]. 2015. Rikkunshito Ameliorates Cancer Cachexia Partly through Elevation of Glucarate in Plasma. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063712
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ohbuchi, Katsuya…[et al.]. Rikkunshito Ameliorates Cancer Cachexia Partly through Elevation of Glucarate in Plasma. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063712
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ohbuchi, Katsuya& Nishiumi, Shin& Fujitsuka, Naoki& Hattori, Tomohisa& Yamamoto, Masahiro& Inui, Akio…[et al.]. Rikkunshito Ameliorates Cancer Cachexia Partly through Elevation of Glucarate in Plasma. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063712
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063712
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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