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Flos Puerariae Extract Ameliorates Cognitive Impairment in Streptozotocin-Induced Diabetic Mice
المؤلفون المشاركون
Liu, Zhong-he
Chen, Hong-guang
Wu, Pan-feng
Yao, Qing
Cheng, Hong-ke
Yu, Wei
Liu, Chao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
The effects of Flos Puerariae extract (FPE) on cognitive impairment associated with diabetes were assessed in C57BL/6J mice.
Methods.
Experimental diabetic mice model was induced by one injection of 50 mg/kg streptozotocin (STZ) for 5 days consecutively.
FPE was orally administrated at the dosages of 50, 100, or 200 mg/kg/day, respectively.
The learning and memory ability was assessed by Morris water maze test.
Body weight, blood glucose, free fatty acid (FFA) and total cholesterol (TCH) in serum, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and acetylcholinesterase (AChE) activities in cerebral cortex and hippocampus were also measured.
Results.
Oral administration of FPE significantly improved cognitive deficits in STZ-induced diabetic mice.
FPE treatment also maintained body weight and ameliorated hyperglycemia and dyslipidemia in diabetic mice.
Additionally, decreased MDA level, enhanced CAT, and GSH-Px activities in cerebral cortex or hippocampus, as well as alleviated AChE activity in cerebral cortex, were found in diabetic mice supplemented with FPE.
Conclusion.
This study suggests that FPE ameliorates memory deficits in experimental diabetic mice, at least partly through the normalization of metabolic abnormalities, ameliorated oxidative stress, and AChE activity in brain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Zhong-he& Chen, Hong-guang& Wu, Pan-feng& Yao, Qing& Cheng, Hong-ke& Yu, Wei…[et al.]. 2015. Flos Puerariae Extract Ameliorates Cognitive Impairment in Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063715
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Zhong-he…[et al.]. Flos Puerariae Extract Ameliorates Cognitive Impairment in Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063715
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Zhong-he& Chen, Hong-guang& Wu, Pan-feng& Yao, Qing& Cheng, Hong-ke& Yu, Wei…[et al.]. Flos Puerariae Extract Ameliorates Cognitive Impairment in Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063715
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063715
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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