Neutrophilic Lung Inflammation Suppressed by Picroside II Is Associated with TGF-β Signaling
المؤلفون المشاركون
Joo, Myungsoo
Kim, Kyun Ha
Noh, Soohwan
Oh, Sei-Ryang
Ahn, Kyung-Seop
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Although acute lung injury (ALI) is a leading cause of death in intensive care unit, effective pharmacologic means to treat ALI patients are lacking.
The rhizome of Picrorhiza scrophulariiflora used in a traditional herbal medicine in Asian countries has been shown to have anti-inflammatory function, and picroside II (PIC II) is known as a major constituent in the plant.
Here, we examined whether PIC II has an anti-inflammatory activity, which is applicable for treating ALI.
We found that although it is not significantly effective in suppressing proinflammatory factor NF-κB or in activating anti-inflammatory factor Nrf2, PIC II induced the phosphorylation of Smad 2, with concomitant increase of luciferase activity from SBE luciferase reporter in RAW 264.7 cells.
H&E staining of lung, differential counting of cells in bronchoalveolar lavage fluid, and semiquantitative RT-PCR analyses of lung tissues show that an intratracheal (i.t.) spraying of PIC II suppressed neutrophilic inflammation and the expression of proinflammatory cytokine genes in the lung, which were elicited by an i.t.
LPS instillation to the lung.
In addition, PIC II treatment increased the phosphorylation of Smad 2 in the lung tissue.
Together, our results suggest that PIC II plays a role as an anti-inflammatory constituent in P.
scrophulariiflora, whose activity is associated at least in part with TGF-β signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Noh, Soohwan& Ahn, Kyung-Seop& Oh, Sei-Ryang& Kim, Kyun Ha& Joo, Myungsoo. 2015. Neutrophilic Lung Inflammation Suppressed by Picroside II Is Associated with TGF-β Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063739
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Noh, Soohwan…[et al.]. Neutrophilic Lung Inflammation Suppressed by Picroside II Is Associated with TGF-β Signaling. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063739
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Noh, Soohwan& Ahn, Kyung-Seop& Oh, Sei-Ryang& Kim, Kyun Ha& Joo, Myungsoo. Neutrophilic Lung Inflammation Suppressed by Picroside II Is Associated with TGF-β Signaling. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063739
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063739
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر