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Antibacterial and Cytotoxic Activity of Compounds Isolated from Flourensia oolepis
المؤلفون المشاركون
Joray, Mariana Belén
Trucco, Lucas Daniel
González, María Laura
Napal, Georgina Natalia Díaz
Palacios, Sara María
Bocco, José Luis
Carpinella, María Cecilia
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The antibacterial and cytotoxic effects of metabolites isolated from an antibacterial extract of Flourensia oolepis were evaluated.
Bioguided fractionation led to five flavonoids, identified as 2′,4′-dihydroxychalcone (1), isoliquiritigenin (2), pinocembrin (3), 7-hydroxyflavanone (4), and 7,4′-dihydroxy-3′-methoxyflavanone (5).
Compound 1 showed the highest antibacterial effect, with minimum inhibitory concentration (MIC) values ranging from 31 to 62 and 62 to 250 μg/mL, against Gram-positive and Gram-negative bacteria, respectively.
On further assays, the cytotoxic effect of compounds 1–5 was determined by MTT assay on acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML) cell lines including their multidrug resistant (MDR) phenotypes.
Compound 1 induced a remarkable cytotoxic activity toward ALL cells (IC50 = 6.6–9.9 μM) and a lower effect against CML cells (IC50 = 27.5–30.0 μM).
Flow cytometry was used to analyze cell cycle distribution and cell death by PI-labeled cells and by Annexin V/PI staining, respectively.
Upon treatment, 1 induced cell cycle arrest in the G2/M phase accompanied by a strong induction of apoptosis.
These results describe for the first time the antibacterial metabolites of F.
oolepis extract, with 1 being the most effective.
This chalcone also emerges as a selective cytotoxic agent against sensitive and resistant leukemic cells, highlighting its potential as a lead compound.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Joray, Mariana Belén& Trucco, Lucas Daniel& González, María Laura& Napal, Georgina Natalia Díaz& Palacios, Sara María & Bocco, José Luis…[et al.]. 2015. Antibacterial and Cytotoxic Activity of Compounds Isolated from Flourensia oolepis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063788
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Joray, Mariana Belén…[et al.]. Antibacterial and Cytotoxic Activity of Compounds Isolated from Flourensia oolepis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063788
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Joray, Mariana Belén& Trucco, Lucas Daniel& González, María Laura& Napal, Georgina Natalia Díaz& Palacios, Sara María & Bocco, José Luis…[et al.]. Antibacterial and Cytotoxic Activity of Compounds Isolated from Flourensia oolepis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063788
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063788
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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