Central Antinociceptive and Mechanism of Action of Pereskia bleo Kunth Leaves Crude Extract, Fractions, and Isolated Compounds
المؤلفون المشاركون
Fernandes, Patricia Dias
Guilhon, Carolina Carvalho
Abdul Wahab, Ikarastika Rahayu
Boylan, Fabio
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Pereskia bleo (Kunth) DC.
(Cactaceae) is a plant commonly used in popular medicine in Malaysia.
In this work, we evaluate the antinociceptive effect of P.
bleo leaf extracts and isolated compounds in central antinociceptive model.
Ethanol extract (E), hexane (H), ethyl acetate (EA), or butanol (B) fractions (30, 50, or 100 mg/kg, p.o.), sitosterol (from hexane) and vitexin (from ethyl acetate), were administered to mice.
Antinociceptive effect was evaluated in the hot plate and capsaicin- or glutamate-induced licking models.
Morphine (1 mg/kg, p.o.) was used as reference drug.
Naloxone (1 mg/kg, i.p.), atropine (1 mg/kg, i.p.), and L-nitro arginine methyl ester (L-NAME, 3 mg/kg, i.p.) were administered 30 min earlier (100 mg/kg, p.o.) in order to evaluate the mechanism of the antinociceptive action.
Higher dose of B developed an effect significantly superior to morphine-treated group.
Naloxone prevented the antinociceptive effect of all fractions.
L-NAME demonstrated effect against E, EA, and B.
In all fractions, sitosterol and vitexin reduced the licking time after capsaicin injection.
Glutamate-induced licking response was blocked by H, EA, and B.
Our results indicate that Pereskia bleo fractions, sitosterol and vitexin, possessed a central antinociceptive effect.
Part of this effect is mediated by opioid receptors and nitrergic pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guilhon, Carolina Carvalho& Abdul Wahab, Ikarastika Rahayu& Boylan, Fabio& Fernandes, Patricia Dias. 2015. Central Antinociceptive and Mechanism of Action of Pereskia bleo Kunth Leaves Crude Extract, Fractions, and Isolated Compounds. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063793
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guilhon, Carolina Carvalho…[et al.]. Central Antinociceptive and Mechanism of Action of Pereskia bleo Kunth Leaves Crude Extract, Fractions, and Isolated Compounds. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063793
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guilhon, Carolina Carvalho& Abdul Wahab, Ikarastika Rahayu& Boylan, Fabio& Fernandes, Patricia Dias. Central Antinociceptive and Mechanism of Action of Pereskia bleo Kunth Leaves Crude Extract, Fractions, and Isolated Compounds. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063793
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063793
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر