Short Term Virologic Efficacies of Telbivudine versus Entecavir against Hepatitis B-Related Hepatocellular Carcinoma
المؤلفون المشاركون
Kim, Young Woon
Nam, Soon Woo
Chung, Eun
Lee, Sung Won
Lee, Jong-yul
Chung, Kyu Won
Kwon, Jung Hyun
Jang, Jeong Won
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Telbivudine has been reported to be more effective than lamivudine.
However, because of the resistance rate to telbivudine (TLV), the current guidelines recommend entecavir (ETV) or tenofovir (TNV) as the first-line therapy for chronic hepatitis B.
We investigated the short term virologic efficacy of TLV in comparison with ETV as the first-line agent of HBV suppression in HBV-related advanced HCC patients.
A total of 86 consecutive patients with HBV-related HCC for whom antiviral treatment was initiated in Incheon St.
Mary’s Hospital between 2010 and 2013 were analyzed.
Virologic responses were investigated on the 4th, 12th, and 24th weeks of the antiviral therapies.
In patients with advanced TNM stage cancer (stage 3 or 4) and poor liver function (Child-Pugh class B or C), the virologic response rates at weeks 12 and 24 were 25% (1/4) and 42.8% (3/7) in the TLV group and 33.3% (1/3) and 33.3% (1/3) in the ETV group, respectively ( P = 0 .
424 , P = 0 .
800 ).
The short term efficacy of TLV was similar to that of ETV.
Since TLV is highly cost-effective, it should be considered as a first-line antiviral agent in patients with advanced HCC, poor liver function, and short life expectancies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Young Woon& Kwon, Jung Hyun& Chung, Eun& Lee, Sung Won& Lee, Jong-yul& Jang, Jeong Won…[et al.]. 2015. Short Term Virologic Efficacies of Telbivudine versus Entecavir against Hepatitis B-Related Hepatocellular Carcinoma. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063927
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Young Woon…[et al.]. Short Term Virologic Efficacies of Telbivudine versus Entecavir against Hepatitis B-Related Hepatocellular Carcinoma. Gastroenterology Research and Practice No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063927
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Young Woon& Kwon, Jung Hyun& Chung, Eun& Lee, Sung Won& Lee, Jong-yul& Jang, Jeong Won…[et al.]. Short Term Virologic Efficacies of Telbivudine versus Entecavir against Hepatitis B-Related Hepatocellular Carcinoma. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063927
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063927
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر