Diabetes and Insulin Therapy, but Not Metformin, Are Related to Hepatocellular Cancer Risk
المؤلفون المشاركون
Grieco, Antonio
Gasbarrini, Antonio
Boccia, Stefania
Turati, Federica
Rapaccini, Gianlodovico
La Vecchia, Carlo
Bosetti, C.
Miele, Luca
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-13
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Introduction.
Metabolic conditions, including type 2 diabetes, have been related to hepatocellular carcinoma (HCC) risk.
We have further analyzed the role of diabetes and antidiabetic treatments on HCC.
Methods.
Data derived from a hospital-based case-control study (Italy, 2005–2012) on 224 HCC patients and 389 controls.
Odds ratios (ORs) were estimated using multiple logistic regression models.
Results.
Sixty-nine (30.9%) cases versus 52 (13.5%) controls reported a diabetes diagnosis, corresponding to a multivariate OR of 2.25 (95% confidence interval, CI = 1.42–3.56).
A stronger excess risk emerged for a longer time since diabetes diagnosis (OR = 2.96 for <10 years and 5.33 for ≥10 years).
Oral therapies were inversely, though not significantly, related to HCC risk, OR being 0.44 for metformin and 0.88 for sulfonylureas; conversely, insulin was nonsignificantly directly associated (OR = 1.90).
Compared to nondiabetic subjects who were never smokers, those who were diabetics and ever smokers had an OR of 6.61 (95% CI 3.31–13.25).
Conclusion.
Our study confirms an over 2-fold excess HCC risk in diabetics, with a stronger excess risk in diabetic subjects who are also tobacco smokers.
Metformin may decrease the risk of HCC, whereas insulin may increase the risk.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miele, Luca& Bosetti, C.& Turati, Federica& Rapaccini, Gianlodovico& Gasbarrini, Antonio& La Vecchia, Carlo…[et al.]. 2015. Diabetes and Insulin Therapy, but Not Metformin, Are Related to Hepatocellular Cancer Risk. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1064051
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miele, Luca…[et al.]. Diabetes and Insulin Therapy, but Not Metformin, Are Related to Hepatocellular Cancer Risk. Gastroenterology Research and Practice No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1064051
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miele, Luca& Bosetti, C.& Turati, Federica& Rapaccini, Gianlodovico& Gasbarrini, Antonio& La Vecchia, Carlo…[et al.]. Diabetes and Insulin Therapy, but Not Metformin, Are Related to Hepatocellular Cancer Risk. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1064051
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1064051
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر