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Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility
المؤلفون المشاركون
Ni, Qing
Ji, Anlai
Yin, Junfeng
Wang, Xiangjun
Liu, Xinnong
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Single nucleotide polymorphisms (SNPs) in genes encoding microRNAs may play important role in the development of gastric cancer.
It has been reported that common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to gastric cancer.
The published results remain inconclusive or even controversial.
A meta-analysis was conducted to quantitatively assess potential association between the two common SNPs and gastric cancer risk.
Methods.
A comprehensive literature search was performed in multiple internet-based electronic databases.
Data from 12 eligible studies were extracted to estimate pooled odds ratios (ORs) and 95% confidence intervals (95% CI).
Results.
C allele of rs2910164 is associated with reduced gastric cancer risk in heterozygote model and dominant model whereas rs11614913 indicates no significant association.
Subgroup analysis demonstrates that C allele of rs2910164 and rs11614913 may decrease susceptibility to diffuse type gastric cancer in dominant model and recessive model, respectively, while rs11614913 increased intestinal type gastric cancer in dominant model.
Conclusion.
SNPs rs2910164 and rs11614913 might have effect on gastric cancer risk in certain genetic models and specific types of cancer.
Further well-designed studies should be considered to validate the potential effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ni, Qing& Ji, Anlai& Yin, Junfeng& Wang, Xiangjun& Liu, Xinnong. 2015. Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1064116
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ni, Qing…[et al.]. Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility. Gastroenterology Research and Practice No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1064116
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ni, Qing& Ji, Anlai& Yin, Junfeng& Wang, Xiangjun& Liu, Xinnong. Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1064116
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1064116
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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