![](/images/graphics-bg.png)
Altered Chemokine Signalling in Endothelial Progenitor Cells from Acute Ulcerative Colitis Patients
المؤلفون المشاركون
De Toni, L.
Di Nisio, A.
Magagna, S.
Michielan, A.
Martinato, M.
Sturniolo, G. C.
D’Incà, R.
Foresta, C.
Garolla, A.
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Ulcerative colitis (UC) is a chronic, idiopathic, inflammatory bowel disease, characterized by alternating stages of clinically active and inactive disease.
UC exhibits several inflammatory characteristics, including immune activation, leukocyte infiltration, and altered vascular density.
In UC, many of the upregulated inflammatory cytokines are proangiogenic and are released by diverse cell populations, such as infiltrating immune cells and endothelial cells (EC).
Increasing evidences suggest that neovascularisation may involve also endothelial progenitor cells (EPCs).
In this study we evaluated EPCs recruitment and homing, assessed by CXCR4 expression, in both acute and remitting phase of UC.
We report an overall decrease of EPCs in UC patients (controls = 97,94 ± 37,34 cells/mL; acute = 31,10 ± 25,38 cells/mL; remitting = 30,33 ± 19,02 cells/mL; P < 0.001 for both UC groups versus controls).
Moreover CXCR4+-EPCs, committed to home in inflammatory conditions, were found to be reduced in acute UC patients compared to both remitting patients and controls (acute = 3,13 ± 4,61 cells/mL; controls = 20,12 ± 14,0; remitting = 19,47 ± 12,83; P < 0,001 ).
Interestingly, we found that administration of anti-inflammatory drugs in acute UC is associated with an increase in circulating EPCs, suggesting that this therapy may exert a strong influence on the progenitor cells response to inflammatory processes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
De Toni, L.& Di Nisio, A.& Magagna, S.& Michielan, A.& Martinato, M.& Sturniolo, G. C.…[et al.]. 2015. Altered Chemokine Signalling in Endothelial Progenitor Cells from Acute Ulcerative Colitis Patients. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064135
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
De Toni, L.…[et al.]. Altered Chemokine Signalling in Endothelial Progenitor Cells from Acute Ulcerative Colitis Patients. Gastroenterology Research and Practice No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1064135
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
De Toni, L.& Di Nisio, A.& Magagna, S.& Michielan, A.& Martinato, M.& Sturniolo, G. C.…[et al.]. Altered Chemokine Signalling in Endothelial Progenitor Cells from Acute Ulcerative Colitis Patients. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064135
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1064135
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)