Effects of Storage Temperature and Time on Stability of Serum Tacrolimus and Cyclosporine A Levels in Whole Blood by LC-MSMS
المؤلفون المشاركون
Kaplan, İbrahim
Yüksel, Hatice
Basarali, M. Kemal
Toprak, Gülten
Çolpan, Leyla
Evliyaoglu, Osman
Şen, Velat
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Tacrolimus and cyclosporine A are immunosuppressant drugs with narrow therapeutic windows.
The aim of this study was to investigate the stability of tacrolimus and cyclosporin A levels in whole blood samples under different storage conditions.
Whole blood samples were obtained from 15 patients receiving tacrolimus and 15 patients receiving cyclosporine A.
Samples were immediately analyzed and then stored at different conditions (room temperature (24°C−26°C) for 24 hours, +4°C for 24 and 48 hours, and −20°C for one month) and then analyzed again.
For tacrolimus, there was a significant difference between samples analyzed immediately and those kept 24 hours at room temperature ( P = 0.005 ) (percent change 32.89%).
However, there were no significant differences between the other groups.
For cyclosporine A, there was a significant difference between samples analyzed immediately and those kept 24 hours ( P = 0.003 ) (percent change 19.47%) and 48 hours ( P = 0.002 ) (percent change 15.38%) at +4°C and those kept 24 hours at room temperature ( P = 0.011 ) (percent change 9.71%).
Samples of tacrolimus should be analyzed immediately or stored at either +4°C or −20°C, while samples of cyclosporine A should be analyzed immediately or stored at −20°C.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kaplan, İbrahim& Yüksel, Hatice& Evliyaoglu, Osman& Basarali, M. Kemal& Toprak, Gülten& Çolpan, Leyla…[et al.]. 2015. Effects of Storage Temperature and Time on Stability of Serum Tacrolimus and Cyclosporine A Levels in Whole Blood by LC-MSMS. International Journal of Analytical Chemistry،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1064459
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kaplan, İbrahim…[et al.]. Effects of Storage Temperature and Time on Stability of Serum Tacrolimus and Cyclosporine A Levels in Whole Blood by LC-MSMS. International Journal of Analytical Chemistry No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1064459
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kaplan, İbrahim& Yüksel, Hatice& Evliyaoglu, Osman& Basarali, M. Kemal& Toprak, Gülten& Çolpan, Leyla…[et al.]. Effects of Storage Temperature and Time on Stability of Serum Tacrolimus and Cyclosporine A Levels in Whole Blood by LC-MSMS. International Journal of Analytical Chemistry. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1064459
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1064459
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر