Expression of Tropomyosin 1 Gene Isoforms in Human Breast Cancer Cell Lines
المؤلفون المشاركون
Dube, Syamalima
Yalamanchili, Santhi
Lachant, Joseph
Abbott, Lynn
Benz, Patricia
Mitschow, Charles
Poiesz, Bernard J.
Dube, D. K.
المصدر
International Journal of Breast Cancer
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Nine malignant breast epithelial cell lines and 3 normal breast cell lines were examined for stress fiber formation and expression of TPM1 isoform-specific RNAs and proteins.
Stress fiber formation was strong (++++) in the normal cell lines and varied among the malignant cell lines (negative to +++).
Although TPM1γ and TPM1δ were the dominant transcripts of TPM1, there was no clear evidence for TPM1δ protein expression.
Four novel human TPM1 gene RNA isoforms were discovered (λ, μ, ν, and ξ), which were not identified in adult and fetal human cardiac tissues.
TPM1λ was the most frequent isoform expressed in the malignant breast cell lines, and it was absent in normal breast epithelial cell lines.
By western blotting, we were unable to distinguish between TPM1γ, λ, and ν protein expression, which were the only TPM1 gene protein isoforms potentially expressed.
Some malignant cell lines demonstrated increased or decreased expression of these isoforms relative to the normal breast cell lines.
Stress fiber formation did not correlate with TPM1γ RNA expression but significantly and inversely correlated with TPM1δ and TPM1λ expression, respectively.
The exact differences in expression of these novel isoforms and their functional properties in breast epithelial cells will require further study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dube, Syamalima& Yalamanchili, Santhi& Lachant, Joseph& Abbott, Lynn& Benz, Patricia& Mitschow, Charles…[et al.]. 2015. Expression of Tropomyosin 1 Gene Isoforms in Human Breast Cancer Cell Lines. International Journal of Breast Cancer،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1065272
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dube, Syamalima…[et al.]. Expression of Tropomyosin 1 Gene Isoforms in Human Breast Cancer Cell Lines. International Journal of Breast Cancer No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1065272
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dube, Syamalima& Yalamanchili, Santhi& Lachant, Joseph& Abbott, Lynn& Benz, Patricia& Mitschow, Charles…[et al.]. Expression of Tropomyosin 1 Gene Isoforms in Human Breast Cancer Cell Lines. International Journal of Breast Cancer. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1065272
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065272
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر