Female Sex Hormones Pattern and Its Relation to Disease Severity and Treatment in Pre- and Postmenopausal Patients with Chronic Hepatitis C Virus (Genotype 4) Infection
المؤلفون المشاركون
Ahmed, Nora H.
El-Abaseri, Taghrid B.
El-Sayed, Hesham F.
El-Serafi, Taher I.
المصدر
International Journal of Chronic Diseases
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Chronic hepatitis C (CHC) course revealed differences between men and women.
Male gender and postmenopausal women are thought to be of the critical factors affecting HCV infection progression.
The study aimed to assess female sex hormones and their relation to disease severity and treatment in HCV infected females.
Subjects were divided to 2 groups: 44 CHC female patients and 44 controls.
Both groups were classified to premenopausal and postmenopausal females.
Serum estradiol (E2), progesterone (PRG), and total testosterone (TT) were assessed using chemiluminescent immunoassay.
Our results showed that menopausal patients had significantly higher levels of estradiol, total testosterone, and progesterone compared to controls ( P < 0.001 ).
Reproductive aged patients had lower level of total testosterone compared to menopausal patients ( P < 0.001 ).
HCV infected females of reproductive age had higher level of progesterone compared to menopausal HCV infected females ( P = 0.0014 ).
Indicators of disease severity and treatment response were significantly worse in menopausal women compared to reproductive aged women (fibrosis: P < 0.001 , activity: P = 0.045 , and treatment: P < 0.001 ).
We observed that lower estradiol level may be related to fibrosis severity in CHC females.
Higher total testosterone and progesterone levels may be related to fibrosis severity and poor response to treatment in CHC menopausal females only.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmed, Nora H.& El-Abaseri, Taghrid B.& El-Sayed, Hesham F.& El-Serafi, Taher I.. 2015. Female Sex Hormones Pattern and Its Relation to Disease Severity and Treatment in Pre- and Postmenopausal Patients with Chronic Hepatitis C Virus (Genotype 4) Infection. International Journal of Chronic Diseases،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065376
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmed, Nora H.…[et al.]. Female Sex Hormones Pattern and Its Relation to Disease Severity and Treatment in Pre- and Postmenopausal Patients with Chronic Hepatitis C Virus (Genotype 4) Infection. International Journal of Chronic Diseases No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065376
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmed, Nora H.& El-Abaseri, Taghrid B.& El-Sayed, Hesham F.& El-Serafi, Taher I.. Female Sex Hormones Pattern and Its Relation to Disease Severity and Treatment in Pre- and Postmenopausal Patients with Chronic Hepatitis C Virus (Genotype 4) Infection. International Journal of Chronic Diseases. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065376
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065376
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر