Association between IFN-γ +874AT and IFN-γR1 (-611AG, +189TG, and +95CT) Gene Polymorphisms and Chronic Periodontitis in a Sample of Iranian Population
المؤلفون المشاركون
Moudi, Bita
Heidari, Zahra
Mahmoudzadeh-Sagheb, Hamidreza
Ansarimoghaddam, Somayeh
Sheibak, Nadia
Hashemi, Mohammad
المصدر
International Journal of Dentistry
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Interferon gamma (IFN-γ) is an immune regulatory cytokine that acts through its receptor and plays important role in progression of inflammatory disease such as chronic periodontitis (CP).
The purpose of this study was to determine the differences in the distribution of IFN-γ (+874A/T) and IFN-γR1 (-611A/G, +189T/G, and +95C/T) gene polymorphisms among CP and healthy individuals and to investigate relationships between these polymorphisms and susceptibility to CP.
Materials and Methods.
310 individuals were enrolled in the study including 210 CP patients and 100 healthy controls.
Single nucleotide polymorphisms at IFN-γ (+874A/T) and IFN-γR1 (-611A/G, +189T/G, and +95C/T) were analyzed by ARMS-PCR and PCR-RFLP methods.
Results.
The significant difference was found in genotype and allele frequency of IFN-γ (+874A/T) gene polymorphism in chronic periodontitis patients and healthy controls.
The distribution of genotypes and allele frequencies for IFN-γR1 (-611A/G, +189T/G, and +95C/T) were similar among the groups and no differences in the frequencies of alleles or genotypes of IFN-γR1 genetic polymorphisms variants between case and control groups were detected.
Conclusion.
The finding of this study showed that IFN-γ +874A/T gene polymorphism may affect susceptibility to CP, whereas IFN-γR1 genetic polymorphisms at -611A/G, +189T/G, and +95C/T were not associated with this disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Heidari, Zahra& Mahmoudzadeh-Sagheb, Hamidreza& Hashemi, Mohammad& Ansarimoghaddam, Somayeh& Moudi, Bita& Sheibak, Nadia. 2016. Association between IFN-γ +874AT and IFN-γR1 (-611AG, +189TG, and +95CT) Gene Polymorphisms and Chronic Periodontitis in a Sample of Iranian Population. International Journal of Dentistry،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065461
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Heidari, Zahra…[et al.]. Association between IFN-γ +874AT and IFN-γR1 (-611AG, +189TG, and +95CT) Gene Polymorphisms and Chronic Periodontitis in a Sample of Iranian Population. International Journal of Dentistry No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065461
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Heidari, Zahra& Mahmoudzadeh-Sagheb, Hamidreza& Hashemi, Mohammad& Ansarimoghaddam, Somayeh& Moudi, Bita& Sheibak, Nadia. Association between IFN-γ +874AT and IFN-γR1 (-611AG, +189TG, and +95CT) Gene Polymorphisms and Chronic Periodontitis in a Sample of Iranian Population. International Journal of Dentistry. 2016. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065461
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065461
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر