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Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data
المؤلفون المشاركون
Zhao, Peng
Hu, Wei
Wang, Hongyun
Yu, Shengyuan
Li, Chuzhong
Bai, Jiwei
Gui, Songbai
Zhang, Yazhuo
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Pituitary adenomas, monoclonal in origin, are the most common intracranial neoplasms.
Altered gene expression as well as somatic mutations is detected frequently in pituitary adenomas.
The purpose of this study was to detect differentially expressed genes (DEGs) and biological processes during tumor formation of pituitary adenomas.
We performed an integrated analysis of publicly available GEO datasets of pituitary adenomas to identify DEGs between pituitary adenomas and normal control (NC) tissues.
Gene function analysis including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and protein-protein interaction (PPI) networks analysis was conducted to interpret the biological role of those DEGs.
In this study we detected 3994 DEGs (2043 upregulated and 1951 downregulated) in pituitary adenoma through an integrated analysis of 5 different microarray datasets.
Gene function analysis revealed that the functions of those DEGs were highly correlated with the development of pituitary adenoma.
This integrated analysis of microarray data identified some genes and pathways associated with pituitary adenoma, which may help to understand the pathology underlying pituitary adenoma and contribute to the successful identification of therapeutic targets for pituitary adenoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Peng& Hu, Wei& Wang, Hongyun& Yu, Shengyuan& Li, Chuzhong& Bai, Jiwei…[et al.]. 2015. Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065574
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Peng…[et al.]. Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065574
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Peng& Hu, Wei& Wang, Hongyun& Yu, Shengyuan& Li, Chuzhong& Bai, Jiwei…[et al.]. Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065574
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065574
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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