Improvement in Depressive Symptoms Is Associated with Reduced Oxidative Damage and Inflammatory Response in Type 2 Diabetic Patients with Subsyndromal Depression: The Results of a Randomized Controlled Trial Comparing Psychoeducation, Physical Exercise, and Enhanced Treatment as Usual
المؤلفون المشاركون
Vučić Lovrenčić, Marijana
Hermanns, Norbert
Pibernik-Okanović, Mirjana
Prašek, Manja
Kos, Jadranka
Ajduković, Dea
Šekerija, Mario
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Aims.
To examine one-year changes in oxidative damage and inflammation level in type 2 diabetic patients undergoing behavioral treatment for subsyndromal depression.
Materials and Methods.
A randomized controlled comparison of psychoeducation (A), physical exercise (B), and enhanced treatment as usual (C) was performed in 209 eligible subjects in a tertiary diabetes care setting.
Depressive symptoms (primary outcome) and selected biomarkers of oxidative damage and inflammation (secondary outcomes) were assessed at baseline and six- and twelve-month follow-up.
Results.
Out of the 74, 67, and 68 patients randomised into groups A, B, and C, respectively, 201 completed the interventions, and 179 were analysed.
Participants in all three groups equally improved in depressive symptoms from baseline to one-year follow-up (repeated measures ANOVA; F=12.51, p<0.0001, η2=0.07).
Urinary 8-oxo-deoxyguanosine (u-8-oxodG) decreased (F=10.66, p<0.0001, η2=0.06), as did sialic acid and leukocytes (F=84.57, η2=0.32 and F=12.61, η2=0.07, resp.; p<0.0001), while uric acid increased (F=12.53, p<0.0001, η2=0.07) in all subjects during one year.
Improvement of depressive symptoms at 6 months significantly predicted one-year reduction in u-8-oxodG (β=0.15, p=0.044).
Conclusion.
Simple behavioral interventions are capable not only of alleviating depressive symptoms, but also of reducing the intensity of damaging oxidative/inflammatory processes in type 2 diabetic patients with subsyndromal depression.
This trial is registered with ISRCTN05673017.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vučić Lovrenčić, Marijana& Pibernik-Okanović, Mirjana& Šekerija, Mario& Prašek, Manja& Ajduković, Dea& Kos, Jadranka…[et al.]. 2015. Improvement in Depressive Symptoms Is Associated with Reduced Oxidative Damage and Inflammatory Response in Type 2 Diabetic Patients with Subsyndromal Depression: The Results of a Randomized Controlled Trial Comparing Psychoeducation, Physical Exercise, and Enhanced Treatment as Usual. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1065591
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vučić Lovrenčić, Marijana…[et al.]. Improvement in Depressive Symptoms Is Associated with Reduced Oxidative Damage and Inflammatory Response in Type 2 Diabetic Patients with Subsyndromal Depression: The Results of a Randomized Controlled Trial Comparing Psychoeducation, Physical Exercise, and Enhanced Treatment as Usual. International Journal of Endocrinology No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1065591
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vučić Lovrenčić, Marijana& Pibernik-Okanović, Mirjana& Šekerija, Mario& Prašek, Manja& Ajduković, Dea& Kos, Jadranka…[et al.]. Improvement in Depressive Symptoms Is Associated with Reduced Oxidative Damage and Inflammatory Response in Type 2 Diabetic Patients with Subsyndromal Depression: The Results of a Randomized Controlled Trial Comparing Psychoeducation, Physical Exercise, and Enhanced Treatment as Usual. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1065591
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065591
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر