Treatment Compliance with Fixed-Dose Combination of VildagliptinMetformin in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Metformin Monotherapy: A 24-Week Observational Study
المؤلفون المشاركون
Rombopoulos, Grigorios
Hatzikou, Magdalini
Athanasiadis, Athanasios
Elisaf, Moses S.
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-19
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate the differences in treatment compliance with vildagliptin/metformin fixed-dose versus free-dose combination therapy in patients with type 2 diabetes mellitus (T2DM) in Greece.
Design.
Adult patients with T2DM, inadequately controlled with metformin monotherapy, (850 mg bid), participated in this 24-week, multicenter, observational study.
Patients were enrolled in two cohorts: vildagliptin/metformin fixed-dose combination (group A) and vildagliptin metformin free-dose combination (group B).
Results.
659 patients were enrolled, 360 were male, with mean BMI 30.1, mean T2DM duration 59.6 months, and mean HbA1c at baseline 8%; 366 patients were assigned to group A and 293 to group B; data for 3 patients was missing.
In group A, 98.9% of patients were compliant with their treatment compared to 84.6% of group B.
The odds ratio for compliance in group A versus B was (OR) 18.9 (95% CI: 6.2, 57.7; P < 0.001 ).
In group A mean HbA1c decreased from 8.1% at baseline to 6.9% ( P < 0.001 ) at the study end and from 7.9% to 6.8% ( P < 0.001 ) in group B.
Conclusions.
Patients in group A were more compliant than patients in group B.
These results are in accordance with international literature suggesting that fixed-dose combination therapies lead to increased compliance to treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rombopoulos, Grigorios& Hatzikou, Magdalini& Athanasiadis, Athanasios& Elisaf, Moses S.. 2015. Treatment Compliance with Fixed-Dose Combination of VildagliptinMetformin in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Metformin Monotherapy: A 24-Week Observational Study. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065605
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rombopoulos, Grigorios…[et al.]. Treatment Compliance with Fixed-Dose Combination of VildagliptinMetformin in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Metformin Monotherapy: A 24-Week Observational Study. International Journal of Endocrinology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1065605
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rombopoulos, Grigorios& Hatzikou, Magdalini& Athanasiadis, Athanasios& Elisaf, Moses S.. Treatment Compliance with Fixed-Dose Combination of VildagliptinMetformin in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Metformin Monotherapy: A 24-Week Observational Study. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065605
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065605
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر