Efficacy of Subantimicrobial Dose Doxycycline for Moderate-to-Severe and Active Graves’ Orbitopathy
المؤلفون المشاركون
Lin, Miaoli
Mao, Yuxiang
Ai, Siming
Liu, Guangming
Zhang, Jian
Yan, Jianhua
Yang, Huasheng
Li, Aimin
Zou, Yusha
Liang, Dan
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
To study the efficacy and safety of subantimicrobial dose (SD) doxycycline(50 mg/d) in patients with active and moderate-to-severe Graves’ orbitopathy (GO).
Methods.
Thirteen patients with active and moderate-to-severe GO received once daily oral doxycycline (50 mg/d) for 12 wk.
Treatment response at 24 wk was used as the primary outcome, measured by a composite of improvement in Clinical Activity Score (CAS), diplopia, motility, soft tissue swelling, proptosis, and eyelid aperture.
Secondary outcome was the change of quality of life score (QoL, including visual functioning subscale and appearance subscale).
Adverse events were also recorded.
Results.
Overall improvement was noted in eight out of 13 patients (61.5%, 95% CI 31.6%–86.1%).
Both CAS and soft tissue swelling significantly ameliorated in eight patients at 24 wk.
Five patients (38.5%) had improvement in ocular motility of ≥8 degrees.
Eyelid aperture (46.2%) also decreased remarkably.
For QoL, a significant improvement in appearance subscale (P=0.008) was noted during the study, whereas no difference was observed in visual functioning subscale (P=0.21).
Two patients reported mild stomachache at 12 wk.
Conclusions.
SD doxycycline appears to be effective and safe for the treatment of active and moderate-to-severe GO.
It might serve as a new promising therapeutic strategy for GO.
This trial is registered with NCT01727973.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Miaoli& Mao, Yuxiang& Ai, Siming& Liu, Guangming& Zhang, Jian& Yan, Jianhua…[et al.]. 2015. Efficacy of Subantimicrobial Dose Doxycycline for Moderate-to-Severe and Active Graves’ Orbitopathy. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065619
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Miaoli…[et al.]. Efficacy of Subantimicrobial Dose Doxycycline for Moderate-to-Severe and Active Graves’ Orbitopathy. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065619
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Miaoli& Mao, Yuxiang& Ai, Siming& Liu, Guangming& Zhang, Jian& Yan, Jianhua…[et al.]. Efficacy of Subantimicrobial Dose Doxycycline for Moderate-to-Severe and Active Graves’ Orbitopathy. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065619
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065619
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر