Low Magnesium Levels and FGF-23 Dysregulation Predict Mitral Valve Calcification as well as Intima Media Thickness in Predialysis Diabetic Patients
المؤلفون المشاركون
Fragoso, André
Silva, Claudia
Guilherme, Patrícia
Santos, Nélio
Faísca, Marilia
Gundlach, Kristina
Büchel, Janine
Jerónimo, Teresa
Neves, Pedro Leão
Silva, Ana Paula
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Mitral valve calcification and intima media thickness (IMT) are common complications of chronic kidney disease (CKD) implicated with high cardiovascular mortality.
Objective.
To investigate the implication of magnesium and fibroblast growth factor-23 (FGF-23) levels with mitral valve calcification and IMT in CKD diabetic patients.
Methods.
Observational, prospective study involving 150 diabetic patients with mild to moderate CKD, divided according to Wilkins Score.
Carotid-echodoppler and transthoracic echocardiography were used to assess calcification.
Statistical tests used to establish comparisons between groups, to identify risk factors, and to establish cut-off points for prediction of mitral valve calcification.
Results.
FGF-23 values continually increased with higher values for both IMT and calcification whereas the opposite trend was observed for magnesium.
FGF-23 and magnesium were found to independently predict mitral valve calcification and IMT (P<0.05).
Using Kaplan-Meier analysis, the number of deaths was higher in patients with lower magnesium levels and poorer Wilkins score.
The mean cut-off value for FGF-23 was 117 RU/mL and for magnesium 1.7 mg/dL.
Conclusions.
Hypomagnesemia and high FGF-23 levels are independent predictors of mitral valve calcification and IMT and are risk factors for cardiovascular mortality in this population.
They might be used as diagnostic/therapeutic targets in order to better manage the high cardiovascular risk in CKD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Silva, Ana Paula& Gundlach, Kristina& Büchel, Janine& Jerónimo, Teresa& Fragoso, André& Silva, Claudia…[et al.]. 2015. Low Magnesium Levels and FGF-23 Dysregulation Predict Mitral Valve Calcification as well as Intima Media Thickness in Predialysis Diabetic Patients. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065626
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Silva, Ana Paula…[et al.]. Low Magnesium Levels and FGF-23 Dysregulation Predict Mitral Valve Calcification as well as Intima Media Thickness in Predialysis Diabetic Patients. International Journal of Endocrinology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065626
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Silva, Ana Paula& Gundlach, Kristina& Büchel, Janine& Jerónimo, Teresa& Fragoso, André& Silva, Claudia…[et al.]. Low Magnesium Levels and FGF-23 Dysregulation Predict Mitral Valve Calcification as well as Intima Media Thickness in Predialysis Diabetic Patients. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065626
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065626
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر