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Cushing’s Disease: The Relevance of a Combined Dexamethasone Desmopressin Test as a Component of Postoperative Hormonal Evaluation
المؤلفون المشاركون
Zieliński, Grzegorz
Witek, Przemysław
Szamotulska, Katarzyna
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The risk of Cushing’s disease (CD) recurring may persist for years, even after initially successful surgery.
Objective.
To prospectively assess the relevance of a combined dexamethasone desmopressin test (CDDT) as a component of postoperative hormonal evaluation, including the dynamics of ACTH and cortisol concentrations.
Material and Methods.
We included 28 patients after TSS for CD.
Eighteen months after surgery the standard hormonal evaluation was performed, followed by a CDDT.
Results.
Fifteen patients (53.6%) were in remission whereas in 13 subjects (46.4%) hypercortisolemia was confirmed.
Positive results of CDDT were observed in 12 noncured patients (92.3%) and in one subject in remission (6.7%).
Negative results were obtained in 12 patients with remission (80%) and in one noncured patient (7.7%).
With 2 patients in CD remission (13.3%) the test results were inconclusive.
We confirmed a high compatibility between CDDT and standard hormonal assessment results (κ=0.846; P<0.001).
Significant differences in ACTH and cortisol levels at each CDDT time point between the two studied subgroups were shown.
Conclusions.
A negative CDDT result can be regarded as one of the factors indicative of CD remission during follow-up.
Additionally, CDDT can help distinguish persistent hypercortisolemia from naturally recurring adrenal function after TSS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Witek, Przemysław& Zieliński, Grzegorz& Szamotulska, Katarzyna. 2015. Cushing’s Disease: The Relevance of a Combined Dexamethasone Desmopressin Test as a Component of Postoperative Hormonal Evaluation. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065657
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Witek, Przemysław…[et al.]. Cushing’s Disease: The Relevance of a Combined Dexamethasone Desmopressin Test as a Component of Postoperative Hormonal Evaluation. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065657
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Witek, Przemysław& Zieliński, Grzegorz& Szamotulska, Katarzyna. Cushing’s Disease: The Relevance of a Combined Dexamethasone Desmopressin Test as a Component of Postoperative Hormonal Evaluation. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065657
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065657
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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