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Methylation of Promoter Regions of Genes of the Human Intrauterine Renin Angiotensin System and Their Expression
المؤلفون المشاركون
Sykes, Shane D.
Mitchell, Carolyn
Pringle, Kirsty G.
Wang, Yu
Lumbers, Eugenie R.
Zakar, Tamas
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The intrauterine renin angiotensin system (RAS) is implicated in placentation and labour onset.
Here we investigate whether promoter methylation of RAS genes changes with gestation or labour and if it affects gene expression.
Early gestation amnion and placenta were studied, as were term amnion, decidua, and placenta collected before labour (at elective caesarean section) or after spontaneous labour and delivery.
The expression and degree of methylation of the prorenin receptor (ATP6AP2), angiotensin converting enzyme (ACE), angiotensin II type 1 receptor (AGTR1), and two proteases that can activate prorenin (kallikrein, KLK1, and cathepsin D, CTSD) were measured by qPCR and a DNA methylation array.
There was no effect of gestation or labour on the methylation of RAS genes and CTSD.
Amnion and decidua displayed strong correlations between the percent hypermethylation of RAS genes and CTSD, suggestive of global methylation.
There were no correlations between the degree of methylation and mRNA abundance of any genes studied.
KLK1 was the most methylated gene and the proportion of hypermethylated KLK1 alleles was lower in placenta than decidua.
The presence of intermediate methylated alleles of KLK1 in early gestation placenta and in amnion after labour suggests that KLK1 methylation is uniquely dynamic in these tissues.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sykes, Shane D.& Mitchell, Carolyn& Pringle, Kirsty G.& Wang, Yu& Zakar, Tamas& Lumbers, Eugenie R.. 2015. Methylation of Promoter Regions of Genes of the Human Intrauterine Renin Angiotensin System and Their Expression. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1065703
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sykes, Shane D.…[et al.]. Methylation of Promoter Regions of Genes of the Human Intrauterine Renin Angiotensin System and Their Expression. International Journal of Endocrinology No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1065703
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sykes, Shane D.& Mitchell, Carolyn& Pringle, Kirsty G.& Wang, Yu& Zakar, Tamas& Lumbers, Eugenie R.. Methylation of Promoter Regions of Genes of the Human Intrauterine Renin Angiotensin System and Their Expression. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1065703
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065703
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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