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A 2-Week Course of Enteral Treatment with a Very Low-Calorie Protein-Based Formula for the Management of Severe Obesity
المؤلفون المشاركون
Castaldo, Giuseppe
Monaco, Luigi
Castaldo, Laura
Sorrentino, Paolo
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Multiple weight loss failures among obese patients suggest the design of new therapeutic strategies.
We investigated the role of 2-week course of enteral treatment with a very low-calorie protein-based formula in the management of severe obesity.
Methods.
We evaluated the feasibility, safety, and efficacy of 2-week continuous administration of a protein-based formula (1.2 g/kg of ideal body weight/day) by nasogastric tube in severely obese adults (body mass index (BMI) ≥ 40 kg/m2).
Results.
In total, 364 patients (59% women; BMI = 46.6±7.2 kg/m2) were recruited.
The intervention was discontinued within 48 hours in 26 patients, due to nasogastric tube intolerance.
No serious adverse events occurred.
During the first and the second week, 65% and 80% patients, respectively, reported no side effects.
All biochemical safety parameters were affected by the intervention, particularly uric acid (+45%) and aminotransferases (+48%).
In the other cases the change was negligible.
We observed significant weight loss (5.7±2.3%) and improvement in blood pressure and glucose and lipid metabolism parameters (P<0.001).
Conclusions.
A 2-week course of enteral treatment with a very low-calorie protein-based formula appeared a feasible, likely safe, and efficacious therapeutic option to be considered for inclusion into a composite weight loss program for the management of severe obesity.
This trial is registered with ClinicalTrials.gov Identifier: NCT01965990.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Castaldo, Giuseppe& Monaco, Luigi& Castaldo, Laura& Sorrentino, Paolo. 2015. A 2-Week Course of Enteral Treatment with a Very Low-Calorie Protein-Based Formula for the Management of Severe Obesity. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065797
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Castaldo, Giuseppe…[et al.]. A 2-Week Course of Enteral Treatment with a Very Low-Calorie Protein-Based Formula for the Management of Severe Obesity. International Journal of Endocrinology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065797
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Castaldo, Giuseppe& Monaco, Luigi& Castaldo, Laura& Sorrentino, Paolo. A 2-Week Course of Enteral Treatment with a Very Low-Calorie Protein-Based Formula for the Management of Severe Obesity. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065797
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065797
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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