Clinical Characteristics and Treatment Outcome of 485 Patients with Nonfunctioning Pituitary Macroadenomas
المؤلفون المشاركون
Vargas, Guadalupe
Gonzalez, Baldomero
Ramirez, Claudia
Ferreira, Aldo
Espinosa, Etual
Mendoza, Victoria
Lopez-Felix, Blas
Mercado, Moisés
Zepeda, Erick
Guinto, Gerardo
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Nonfunctioning pituitary adenomas (NFPAs) are the most common benign lesions of the pituitary gland.
Objective.
To describe our experience with the management of NFPA.
Study Design and Methods.
Retrospective evaluation of NFPA patients managed between 2008 and 2013.
We analyzed data regarding clinical presentation, imaging diagnosis, hormonal status, surgical, radiotherapeutic, and pharmacological treatment, and outcome.
Results.
485 patients (54% men, mean age 53±14 years) were followed for a median of 6.5 years.
Visual field abnormalities and headaches were the presenting complaints in 87% and 66%, respectively.
The diagnosis of NFPA was made incidentally in 6.2%, and 8% presented with clinical evidence of apoplexy.
All patients harbored macroadenomas, with a median volume of 10306 mm3; 57.9% had supra- or parasellar invasion and 19.6% had tumors larger than 4 cm.
Central hypothyroidism, hypogonadism, and hypocortisolism were present in 47.2%, 35.9%, and 27.4%, respectively.
Surgical resection was performed at least once in 85.7%.
Tumor persistence was documented in 27% and was related to the size and invasiveness of the lesion.
In selected cases, radiotherapy proved to be effective in controlling or preventing tumor growth.
Conclusions.
The diagnosis and treatment of NFPA are complex and require a multidisciplinary approach.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vargas, Guadalupe& Gonzalez, Baldomero& Ramirez, Claudia& Ferreira, Aldo& Espinosa, Etual& Mendoza, Victoria…[et al.]. 2015. Clinical Characteristics and Treatment Outcome of 485 Patients with Nonfunctioning Pituitary Macroadenomas. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065804
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vargas, Guadalupe…[et al.]. Clinical Characteristics and Treatment Outcome of 485 Patients with Nonfunctioning Pituitary Macroadenomas. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065804
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vargas, Guadalupe& Gonzalez, Baldomero& Ramirez, Claudia& Ferreira, Aldo& Espinosa, Etual& Mendoza, Victoria…[et al.]. Clinical Characteristics and Treatment Outcome of 485 Patients with Nonfunctioning Pituitary Macroadenomas. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065804
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065804
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر