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The “Lipid Accumulation Product” Is Associated with 2-Hour Postload Glucose Outcomes in OverweightObese Subjects with Nondiabetic Fasting Glucose
المؤلفون المشاركون
Rondanelli, Mariangela
Malavazos, Alexis Elias
Cereda, Emanuele
Ermetici, Federica
Caccialanza, Riccardo
Briganti, Silvia
Morricone, Lelio
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
“Lipid accumulation product” (LAP) is a continuous variable based on waist circumference and triglyceride concentration previously associated with insulin resistance.
We investigated the accuracy of LAP in identifying oral glucose tolerance test (OGTT) abnormalities and compared it to the homeostasis model assessment of insulin resistance (HOMA-IR) in a population of overweight/obese outpatients presenting with nondiabetic fasting glucose.
We studied 381 (male: 23%) adult (age: 18–70 years) overweight/obese Caucasians (body mass index: 36.9 ± 5.4 Kg/m2) having fasting plasma glucose < 7.0 mmol/L.
OGTT was used to diagnose unknown glucose tolerance abnormalities: impaired glucose tolerance (IGT) and type-2 diabetes mellitus (T2-DM).
According to OGTT 92, subjects had an IGT and 33 were diagnosed T2-DM.
Logistic regression analysis detected a significant association for both LAP and HOMA-IR with single (IGT and T2-DM) and composite (IGT + T2-DM) abnormal glucose tolerance conditions.
However, while the association with diabetes was similar between LAP and HOMA-IR, the relationship with IGT and composite outcomes by models including LAP was significantly superior to those including HOMA-IR (P=0.006 and P=0.007, resp.).
LAP seems to be an accurate index, performing better than HOMA-IR, for identifying 2-hour postload OGTT outcomes in overweight/obese patients with nondiabetic fasting glucose.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Malavazos, Alexis Elias& Cereda, Emanuele& Ermetici, Federica& Caccialanza, Riccardo& Briganti, Silvia& Rondanelli, Mariangela…[et al.]. 2015. The “Lipid Accumulation Product” Is Associated with 2-Hour Postload Glucose Outcomes in OverweightObese Subjects with Nondiabetic Fasting Glucose. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065827
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Malavazos, Alexis Elias…[et al.]. The “Lipid Accumulation Product” Is Associated with 2-Hour Postload Glucose Outcomes in OverweightObese Subjects with Nondiabetic Fasting Glucose. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065827
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Malavazos, Alexis Elias& Cereda, Emanuele& Ermetici, Federica& Caccialanza, Riccardo& Briganti, Silvia& Rondanelli, Mariangela…[et al.]. The “Lipid Accumulation Product” Is Associated with 2-Hour Postload Glucose Outcomes in OverweightObese Subjects with Nondiabetic Fasting Glucose. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065827
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065827
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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