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The “Lipid Accumulation Product” Is Associated with 2-Hour Postload Glucose Outcomes in OverweightObese Subjects with Nondiabetic Fasting Glucose
Joint Authors
Rondanelli, Mariangela
Malavazos, Alexis Elias
Cereda, Emanuele
Ermetici, Federica
Caccialanza, Riccardo
Briganti, Silvia
Morricone, Lelio
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
“Lipid accumulation product” (LAP) is a continuous variable based on waist circumference and triglyceride concentration previously associated with insulin resistance.
We investigated the accuracy of LAP in identifying oral glucose tolerance test (OGTT) abnormalities and compared it to the homeostasis model assessment of insulin resistance (HOMA-IR) in a population of overweight/obese outpatients presenting with nondiabetic fasting glucose.
We studied 381 (male: 23%) adult (age: 18–70 years) overweight/obese Caucasians (body mass index: 36.9 ± 5.4 Kg/m2) having fasting plasma glucose < 7.0 mmol/L.
OGTT was used to diagnose unknown glucose tolerance abnormalities: impaired glucose tolerance (IGT) and type-2 diabetes mellitus (T2-DM).
According to OGTT 92, subjects had an IGT and 33 were diagnosed T2-DM.
Logistic regression analysis detected a significant association for both LAP and HOMA-IR with single (IGT and T2-DM) and composite (IGT + T2-DM) abnormal glucose tolerance conditions.
However, while the association with diabetes was similar between LAP and HOMA-IR, the relationship with IGT and composite outcomes by models including LAP was significantly superior to those including HOMA-IR (P=0.006 and P=0.007, resp.).
LAP seems to be an accurate index, performing better than HOMA-IR, for identifying 2-hour postload OGTT outcomes in overweight/obese patients with nondiabetic fasting glucose.
American Psychological Association (APA)
Malavazos, Alexis Elias& Cereda, Emanuele& Ermetici, Federica& Caccialanza, Riccardo& Briganti, Silvia& Rondanelli, Mariangela…[et al.]. 2015. The “Lipid Accumulation Product” Is Associated with 2-Hour Postload Glucose Outcomes in OverweightObese Subjects with Nondiabetic Fasting Glucose. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065827
Modern Language Association (MLA)
Malavazos, Alexis Elias…[et al.]. The “Lipid Accumulation Product” Is Associated with 2-Hour Postload Glucose Outcomes in OverweightObese Subjects with Nondiabetic Fasting Glucose. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065827
American Medical Association (AMA)
Malavazos, Alexis Elias& Cereda, Emanuele& Ermetici, Federica& Caccialanza, Riccardo& Briganti, Silvia& Rondanelli, Mariangela…[et al.]. The “Lipid Accumulation Product” Is Associated with 2-Hour Postload Glucose Outcomes in OverweightObese Subjects with Nondiabetic Fasting Glucose. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065827