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Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women
المؤلفون المشاركون
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background and Aim.
Leptin has two forms in the circulation: free and bound forms.
The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin.
The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens.
Methods.
A cross-sectional study included 78 female students aged 17–25 years.
Fasting serum leptin and sOB-R concentrations were measured.
The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed.
Results.
In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects.
In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98–48.04) and decreased sOB-R in ng/ml 11.47 (7.59–16.44) compared to lean PCOS 16.97 (10.60–45.55) for leptin and 16.62 (11.61–17.96) for sOB-R with p values 0.013 and 0.042, respectively.
However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected.
Conclusion.
PCOS is associated with hyperleptinemia and increased free leptin index.
Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rizk, Nasser M.& Sharif, Elham. 2015. Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065887
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rizk, Nasser M.& Sharif, Elham. Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women. International Journal of Endocrinology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065887
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rizk, Nasser M.& Sharif, Elham. Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065887
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065887
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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