The Relations between EGFR R521K Polymorphism and Risk of Cancer: Need for Clarification of Data in a Recent Meta-Analysis

الملخص EN

Recently we read with great interest the paper by Wang et al.

[1].

The authors conducted a meta-analysis of 13 studies containing 7328 cases and 8455 controls to estimate the association of R521K polymorphism in EGFR gene with risk of cancer.

This meta-analysis suggested that the EGFR R521K polymorphism is not associated with risk of cancer except a statistical difference between A and G allele frequencies in gastric cancer.

It is a valuable study.

Nevertheless, we would like to raise several concerns related to this article.