Cytokines Modulate the “Immune-Metabolism” Interactions during Behçet Disease: Effect on Arginine Metabolism
المؤلفون المشاركون
Touil-Boukoffa, Chafia
Belguendouz, Houda
Lahmar-Belguendouz, Karima
Messaoudene, Djamel
Djeraba, Zineb
Otmani, Fifi
Hakem, Djennat
Lahlou-Boukoffa, Ouided S.
Youinou, Pierre
المصدر
International Journal of Inflammation
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aim and Methods.
In this study, we evaluated NOS and arginase activities and their regulation during Behçet disease, a systemic chronic inflammatory disorder with uncertain etiology.
The peripheral blood mononuclear cells of 36 patients and 15 control samples (PBMC) were cultured in either RPMI 1640, MEM, or DMEM complemented with 10% of FBS and antibiotics.
Cultures were performed with or without the control or patients plasma.
Subsequent treatment contained anticytokines (IL-6, TGF-β), a mitogenic effector (PHA), or NOS modulators (L-NMMA, BH4).
Culture supernatants were harvested after 24 h of incubation.
NO and urea measurements were, respectively, performed by modified Griess and Berthelot methods.
Results.
Higher urea levels were found in patients’ plasma compared to the control’s (P < 0.05).
NOS modulators induced inverted production profiles for NO and urea (P < 0.05).
Their results differed depending on the clinical findings (P < 0.05).
It was also found that cytokine neutralization induced different response profiles in patients as opposed to control cultures (P < 0.05).
Conclusion.
Our results suggest that arginases can compete with NOS2 for L-arginine during Behçet disease.
Both enzymes are regulated by environmental cytokines and substrate availability.
Furthermore, it seems that NOS/arginase balance is dependent on clinical expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Belguendouz, Houda& Lahmar-Belguendouz, Karima& Messaoudene, Djamel& Djeraba, Zineb& Otmani, Fifi& Hakem, Djennat…[et al.]. 2015. Cytokines Modulate the “Immune-Metabolism” Interactions during Behçet Disease: Effect on Arginine Metabolism. International Journal of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066141
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Belguendouz, Houda…[et al.]. Cytokines Modulate the “Immune-Metabolism” Interactions during Behçet Disease: Effect on Arginine Metabolism. International Journal of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1066141
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Belguendouz, Houda& Lahmar-Belguendouz, Karima& Messaoudene, Djamel& Djeraba, Zineb& Otmani, Fifi& Hakem, Djennat…[et al.]. Cytokines Modulate the “Immune-Metabolism” Interactions during Behçet Disease: Effect on Arginine Metabolism. International Journal of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066141
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066141
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر