Effect of Pentoxifylline on Microalbuminuria in Diabetic Patients: A Randomized Controlled Trial
المؤلفون المشاركون
Shahidi, Shahrzad
Iraj, Bijan
Hoseinbalam, Marziyeh
Akbari, Mojtaba
المصدر
International Journal of Nephrology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Pentoxifylline is a nonspecific phosphodiesterase inhibitor with anti-inflammatory properties.
Human studies have proved its antiproteinuric effect in patients with glomerular diseases, but this study was designed to assess the effects of add-on pentoxifylline to available treatment on reduction of microalbuminuria in diabetic patients without glomerular diseases.
Methods.
In a double-blind placebo-controlled, randomized study we evaluated the influence of pentoxifylline on microalbuminuria in type 2 diabetic patients.
40 diabetic patients with estimated glomerular filtration rate (eGFR) of more than 60 mL/min/1.73 m2 in eight weeks and microalbuminuria were randomized to two groups which will receive pentoxifylline 1200 mg/day or placebo added to regular medications for 6 months.
albuminuria; eGFR was evaluated at three- and six-month follow-up period.
Results.
Baseline characteristics were similar between the two groups.
At six months, the mean estimated GFR and albuminuria were not different between two groups at 3- and 6-month follow-up.
Trend of albumin to creatinine ratio, systolic and diastolic blood pressure, and eGFR in both groups were decreased, but no significant differences were noted between two groups ( P value > 0.05).
Conclusion.
Pentoxifylline has not a significant additive antimicroalbuminuric effect compared with placebo in patients with type 2 diabetes with early stage of kidney disease; however, further clinical investigations are necessary to be done.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shahidi, Shahrzad& Hoseinbalam, Marziyeh& Iraj, Bijan& Akbari, Mojtaba. 2015. Effect of Pentoxifylline on Microalbuminuria in Diabetic Patients: A Randomized Controlled Trial. International Journal of Nephrology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066227
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shahidi, Shahrzad…[et al.]. Effect of Pentoxifylline on Microalbuminuria in Diabetic Patients: A Randomized Controlled Trial. International Journal of Nephrology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1066227
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shahidi, Shahrzad& Hoseinbalam, Marziyeh& Iraj, Bijan& Akbari, Mojtaba. Effect of Pentoxifylline on Microalbuminuria in Diabetic Patients: A Randomized Controlled Trial. International Journal of Nephrology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066227
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066227
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر