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Hyperuricemia: An Early Marker for Severity of Illness in Sepsis
المؤلفون المشاركون
Alhajhusain, Ahmad
Ali, Ailia W.
Hussain, Kashif
Akbar, Sana R.
Long, Dustin M.
Ahmed, Umair S.
Iqbal, Hafiz I.
Leonard, Rachel
Dalton, Cheryl
المصدر
International Journal of Nephrology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Uric acid can acutely activate various inflammatory transcription factors.
Since high levels of oxyradicals and lower antioxidant levels in septic patients are believed to result in multiorgan failure, uric acid levels could be used as a marker of oxidative stress and poor prognosis in patients with sepsis.
Design.
We conducted a prospective cohort study on Medical Intensive Care Unit (MICU) patients and hypothesized that elevated uric acid in patients with sepsis is predictive of greater morbidity.
The primary end point was the correlation between hyperuricemia and the morbidity rate.
Secondary end points were Acute Kidney Injury (AKI), mortality, Acute Respiratory Distress Syndrome (ARDS), and duration of stay.
Results.
We enrolled 144 patients.
54 (37.5%) had the primary end point of hyperuricemia.
The overall morbidity rate was 85.2%.
The probability of having hyperuricemia along with AKI was 68.5% and without AKI was 31.5%.
Meanwhile the probability of having a uric acid value <7 mg/dL along with AKI was 18.9% and without AKI was 81.1% ( p value < 0.0001).
Conclusion.
We report that elevated uric acid levels on arrival to the MICU in patients with sepsis are associated with poor prognosis.
These patients are at an increased risk for AKI and ARDS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Akbar, Sana R.& Long, Dustin M.& Hussain, Kashif& Alhajhusain, Ahmad& Ahmed, Umair S.& Iqbal, Hafiz I.…[et al.]. 2015. Hyperuricemia: An Early Marker for Severity of Illness in Sepsis. International Journal of Nephrology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066228
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Akbar, Sana R.…[et al.]. Hyperuricemia: An Early Marker for Severity of Illness in Sepsis. International Journal of Nephrology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1066228
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Akbar, Sana R.& Long, Dustin M.& Hussain, Kashif& Alhajhusain, Ahmad& Ahmed, Umair S.& Iqbal, Hafiz I.…[et al.]. Hyperuricemia: An Early Marker for Severity of Illness in Sepsis. International Journal of Nephrology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066228
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066228
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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