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High (≥6.5) Spontaneous and Persistent Urinary pH Is Protective of Renal Function at Baseline and during Disease Course in Idiopathic Membranous Nephropathy
المؤلفون المشاركون
Rizza, Virginia
Casellato, Daniela
Tagliabue, Elena
Raimondi, Sara
Nangaku, Masaomi
Bazzi, Claudio
المصدر
International Journal of Nephrology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Metabolic acidosis correction in advanced renal failure slows renal function decline attributed to tubulointerstitial damage (TID) reduction.
No study evaluated if spontaneous baseline high urinary pH (UpH) is renoprotective in patients with normal renal function and without metabolic acidosis.
The study tested this hypothesis in idiopathic membranous nephropathy (IMN).
Eighty-five patients (follow-up 81 ± 54 months) measured UpH, serum creatinine, eGFR, protein/creatinine ratio, fractional excretion of albumin, IgG, α1-microglobulin, and urinary N-acetyl-β-D-glucosaminidase (β-NAG)/creatinine ratio.
Twenty-eight patients (33%) had UpH ≥ 6.5 and 57 (67%) pH < 6.5; high versus low UpH patients had significantly lower values of the tubulointerstitial damage (TID) markers FE α1m and β-NAG and significantly better baseline renal function.
These differences persisted over time in a subset of 38 patients with 5 measurements along 53 ± 26 months.
In 29 patients with nephrotic syndrome (NS) treated with supportive therapy (follow-up: 80 ± 52 months) renal function was stable in 10 high and significantly worse in 19 low UpH patients.
Steroids + cyclophosphamide treatment in 35 NS patients masks the renoprotection of high UpH.
Conclusions.
In IMN high and persistent UpH is associated with reduction of the proteinuric markers of tubulointerstitial damage and baseline better renal function in all patients and in NS patients treated only with supportive therapy during disease course.
The factors associated with high pH-dependent renoprotection were lower values of TID markers, eGFR ≥ 60 mL/min, BP < 140/90 mmHg, and age < 55 years.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bazzi, Claudio& Tagliabue, Elena& Raimondi, Sara& Rizza, Virginia& Casellato, Daniela& Nangaku, Masaomi. 2015. High (≥6.5) Spontaneous and Persistent Urinary pH Is Protective of Renal Function at Baseline and during Disease Course in Idiopathic Membranous Nephropathy. International Journal of Nephrology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066240
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bazzi, Claudio…[et al.]. High (≥6.5) Spontaneous and Persistent Urinary pH Is Protective of Renal Function at Baseline and during Disease Course in Idiopathic Membranous Nephropathy. International Journal of Nephrology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1066240
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bazzi, Claudio& Tagliabue, Elena& Raimondi, Sara& Rizza, Virginia& Casellato, Daniela& Nangaku, Masaomi. High (≥6.5) Spontaneous and Persistent Urinary pH Is Protective of Renal Function at Baseline and during Disease Course in Idiopathic Membranous Nephropathy. International Journal of Nephrology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1066240
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066240
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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