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Morphological Retrospective Study of Peritoneal Biopsies from Patients with Encapsulating Peritoneal Sclerosis: Underestimated Role of Adipocytes as New Fibroblasts Lineage?
المؤلفون المشاركون
Tooulou, Monika
Nortier, Joëlle L.
Demetter, Pieter
Keyzer, Caroline
Pozdzik, Agnieszka
Hamade, Anwar
المصدر
International Journal of Nephrology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication of peritoneal dialysis (PD).
Besides the endothelial-to-mesenchymal transition (EMT), recently peritoneal adipocytes emerged as a potential source of fibrosis.
We performed immunohistochemistry to approach EMT and to localize peritoneal adipocytes in peritoneal biopsies from PD-related EPS patients.
Material and Methods.
We investigated tissue expression of podoplanin, cytokeratin AE1/AE3 (mesothelium), calretinin (adipocytes), alpha-smooth muscle actin [α-SMA] (mesenchymal cells), interstitial mononuclear cell inflammation, and neoangiogenesis (CD3, CD4, CD8, CD20, CD68, and CD31 immunostainings, resp.).
Results.
Three patients (1 man/2 women; 17, 64, and 39 years old, resp.) developed EPS after 21, 90, and 164 months of PD therapy.
In patients with EPS, we observed (1) loss of AE1/AE3 cytokeratin+ mesothelial cells without any evidence of migration into the interstitium, (2) disappearance of adipose tissue, (3) diffuse infiltration of calretinin+ cells in the areas of submesothelial fibrosis with a huge number of α-SMA and calretinin+ fusiform cells, and (4) increased vascular density.
Conclusion.
We report that the involvement of EMT in peritoneal fibrosis is difficult to demonstrate and that the calretinin+ adipocytes might be an underestimated component and a new source of myofibroblasts in peritoneal remodeling during PD-related EPS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tooulou, Monika& Demetter, Pieter& Hamade, Anwar& Keyzer, Caroline& Nortier, Joëlle L.& Pozdzik, Agnieszka. 2015. Morphological Retrospective Study of Peritoneal Biopsies from Patients with Encapsulating Peritoneal Sclerosis: Underestimated Role of Adipocytes as New Fibroblasts Lineage?. International Journal of Nephrology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1066245
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tooulou, Monika…[et al.]. Morphological Retrospective Study of Peritoneal Biopsies from Patients with Encapsulating Peritoneal Sclerosis: Underestimated Role of Adipocytes as New Fibroblasts Lineage?. International Journal of Nephrology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1066245
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tooulou, Monika& Demetter, Pieter& Hamade, Anwar& Keyzer, Caroline& Nortier, Joëlle L.& Pozdzik, Agnieszka. Morphological Retrospective Study of Peritoneal Biopsies from Patients with Encapsulating Peritoneal Sclerosis: Underestimated Role of Adipocytes as New Fibroblasts Lineage?. International Journal of Nephrology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1066245
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066245
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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