Water-Solubilization of P(V)‎ and Sb(V)‎ Porphyrins and Their Photobiological Application

الملخص EN

Porphyrins have been widely utilized as biochemical and biological functional chromophores which can operate under visible-light irradiation.

Water-soluble porphyrins have been used as the drug for photodynamic therapy (PDT) and photodynamic inactivation (PDI).

Although usual water-solubilization of porphyrins has been achieved by an introduction of an ionic group such as ammonium, pyridinium, sulfonate, phosphonium, or carboxyl to porphyrin ring, we proposed the preparation of water-soluble P and Sb porphyrins by modification of axial ligands.

Alkyl (type A), ethylenedioxy (type E), pyridinium (type P), and glucosyl groups (type G) were introduced to axial ligands of Sb and P porphyrins to achieve water-solubilization of Sb porphyrin and P porphyrins.

Here, we review their water-soluble P and Sb porphyrins from the standpoints of preparation, bioaffinity, and photosensitized inactivation.