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Synthesis and Characterization of New Thiolated Chitosan Nanoparticles Obtained by Ionic Gelation Method
المؤلفون المشاركون
Valdez, Miguel A.
Esquivel, Reynaldo
Juárez, Josué
Almada, Mario
Ibarra, Jaime
المصدر
International Journal of Polymer Science
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-15
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
We derivatized low molecular weight chitosan (LMWC) with 3-mercaptopropanoic acid (3-MPA) by a coupling reaction.
The chemical modification of LMWC was characterized by Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance, 1HNMR.
We researched the influence of 3-MPA on the nanoparticles formation by ionic gelation method using sodium tripolyphosphate (TPP) as cross-linker reagent.
In order to optimize the nanoparticles formation, we studied the effect of the pH solution and molar ratio on nanoparticles stability.
Analyses of particle size, morphology, and surface charge were determined by dynamic light scattering, Atomic Force Microscopy, and zeta potential, respectively.
It was found that formation of semispherical and stable nanoparticles was improved due to the chemical modification of chitosan.
Optimized semispherical nanoparticles of thiolated chitosan were synthesized with the parameters (pH 4.7, molar ratios 1 : 106).
Additionally, we reported the thermodynamic profile of the nanoparticles formation determined by isothermal titration calorimetry (ITC).
The aggregation process achieved to form nanoparticles of thiolated and nonmodified chitosan consisted of two stages, considering one binding site model.
Gibbs free energy ( Δ G ) and binding constant ( K a ) describe the aggregation process of thiolated chitosan/TPP, which is an initial reaction and followed by an endothermic stage.
These results are promising for the possible application of these nanoparticles as nanocarriers and delivery systems.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Esquivel, Reynaldo& Juárez, Josué& Almada, Mario& Ibarra, Jaime& Valdez, Miguel A.. 2015. Synthesis and Characterization of New Thiolated Chitosan Nanoparticles Obtained by Ionic Gelation Method. International Journal of Polymer Science،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1066789
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Esquivel, Reynaldo…[et al.]. Synthesis and Characterization of New Thiolated Chitosan Nanoparticles Obtained by Ionic Gelation Method. International Journal of Polymer Science No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1066789
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Esquivel, Reynaldo& Juárez, Josué& Almada, Mario& Ibarra, Jaime& Valdez, Miguel A.. Synthesis and Characterization of New Thiolated Chitosan Nanoparticles Obtained by Ionic Gelation Method. International Journal of Polymer Science. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1066789
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066789
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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