Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery
المؤلفون المشاركون
Chen, Pin
Wang, Xin
Dong, Yan
Zhang, Guojun
المصدر
International Journal of Polymer Science
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Hydrogel is a kind of attractive drug carriers because of its good biocompatibility and transparency.
But traditional hydrogel showed some restrictions in its application in ocular drug delivery.
A simple surface modification technique based on layer-by-layer (LbL) self-assembled multilayer for ocular drug delivery was developed in this work.
Polycarboxymethyl-β-cyclodextrin (poly(CM-β-CD))/poly-l-lysine (PLL) multilayer film was designed and constructed for ocular drug delivery, since β-CD showed good drug delivery property.
The properties such as the contact angle and transparency varied a little with the deposition of poly(CM-β-CD)/PLL multilayer.
Orfloxacin and puerarin were loaded into multilayer during the self-assembly procedure by two methods, which were tracked by the largest drug absorbance of UV spectrum.
The loaded drug amount by incorporating drugs into poly(CM-β-CD) solution was larger than that by incorporating drugs into PLL solution.
The loaded drug in the multilayer could gradually be released from multilayer in some period either for orfloxacin or for puerarin.
The drug release behavior was influenced by drug loading method and pH value of released medium.
Moreover, the balanced released drug amount by incorporating drugs into poly(CM-β-CD) solution is much smaller than that by incorporating drugs into PLL solution.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Pin& Wang, Xin& Dong, Yan& Zhang, Guojun. 2015. Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery. International Journal of Polymer Science،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066796
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Pin…[et al.]. Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery. International Journal of Polymer Science No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1066796
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Pin& Wang, Xin& Dong, Yan& Zhang, Guojun. Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery. International Journal of Polymer Science. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066796
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066796
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر