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Adding Streptomycin to an Intensified Regimen for Tuberculous Meningitis Improves Survival in HIV-Infected Patients
المؤلفون المشاركون
Alvarez-Uria, Gerardo
Midde, Manoranjan
Yalla, Pradeep S.
Pakam, Raghavakalyan
Naik, Praveen K.
المصدر
Interdisciplinary Perspectives on Infectious Diseases
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-04
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
In low- and middle-income countries, the mortality of HIV-associated tuberculous meningitis (TM) continues to be unacceptably high.
In this observational study of 228 HIV-infected patients with TM, we compared the mortality during the first nine months of patients treated with standard antituberculosis therapy (sATT), intensified ATT (iATT), and iATT with streptomycin (iATT + STM).
The iATT included levofloxacin, ethionamide, pyrazinamide, and double dosing of rifampicin and isoniazid and was given only during the hospital admission (median 7 days, interquartile range 6–9).
No mortality differences were seen in patients receiving the sATT and the iATT.
However, patients receiving the iATT + STM had significant lower mortality than those in the sATT group (hazard ratio [HR] 0.47, 95% confidence interval [CI] 0.24 to 0.93).
After adjusting for other covariates, the mortality hazard of the iATT + STM versus the sATT remained statistically significant (adjusted HR 0.2, 95% CI 0.09 to 0.46).
Other factors associated with mortality were previous ATT and low albumin concentrations.
The mortality risk increased exponentially only with CD4+ lymphocyte concentrations below 100 cells/μL.
In conclusion, the use of iATT resulted in a clinically important reduction in mortality compared with the standard of care only if associated with STM.
The results of this study deserve further research.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alvarez-Uria, Gerardo& Pakam, Raghavakalyan& Midde, Manoranjan& Yalla, Pradeep S.& Naik, Praveen K.. 2015. Adding Streptomycin to an Intensified Regimen for Tuberculous Meningitis Improves Survival in HIV-Infected Patients. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1067004
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alvarez-Uria, Gerardo…[et al.]. Adding Streptomycin to an Intensified Regimen for Tuberculous Meningitis Improves Survival in HIV-Infected Patients. Interdisciplinary Perspectives on Infectious Diseases No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1067004
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alvarez-Uria, Gerardo& Pakam, Raghavakalyan& Midde, Manoranjan& Yalla, Pradeep S.& Naik, Praveen K.. Adding Streptomycin to an Intensified Regimen for Tuberculous Meningitis Improves Survival in HIV-Infected Patients. Interdisciplinary Perspectives on Infectious Diseases. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1067004
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067004
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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