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A Useful Strategy to Evaluate the Quality Consistency of Traditional Chinese Medicines Based on Liquid Chromatography and Chemometrics
المؤلفون المشاركون
Wang, Pei
Nie, Lei
Zang, Hengchang
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Evaluation of the batch consistency of traditional Chinese medicines (TCMs) is essential for the promotion of the development and quality control of TCMs.
The aim of the present work was to develop a useful strategy via liquid chromatography and chemometrics to evaluate the batch consistency of TCM preparations.
Xin-Ke-Shu (XKS) tablet was chosen as a model for this method development.
Four types of chromatographic fingerprint approaches were compared by using similarity analysis based on cosine of angel or correlation coefficient.
Differences in the fingerprints of 71 batches of XKS tablet were illustrated by hierarchical cluster analysis.
Then, Mahalanobis distance was employed for estimating the probability level ( P < 0.05 ) of the differences mentioned above.
Additionally, t-test was applied to find out the chromatographic peaks which had significant differences.
For XKS tablet, the maximum wavelength fingerprint had the largest range and dispersion degree of similarity as compared with the other three ones.
There were two clear clusters in all the batches of samples.
And we clearly arrived at the conclusion that higher similarity does not exactly indicate small Mahalanobis distance, while lower similarity indicated larger Mahalanobis distance.
Finally, a useful strategy was proposed for evaluation of the batch consistency of XKS tablet.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Pei& Nie, Lei& Zang, Hengchang. 2015. A Useful Strategy to Evaluate the Quality Consistency of Traditional Chinese Medicines Based on Liquid Chromatography and Chemometrics. Journal of Analytical Methods in Chemistry،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067212
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Pei…[et al.]. A Useful Strategy to Evaluate the Quality Consistency of Traditional Chinese Medicines Based on Liquid Chromatography and Chemometrics. Journal of Analytical Methods in Chemistry No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1067212
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Pei& Nie, Lei& Zang, Hengchang. A Useful Strategy to Evaluate the Quality Consistency of Traditional Chinese Medicines Based on Liquid Chromatography and Chemometrics. Journal of Analytical Methods in Chemistry. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067212
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067212
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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