10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling
المؤلفون المشاركون
Ichihara, Kenji
Hata, Taketoshi
Araki, Yoko
Honda, Yoko
Ito, Masafumi
Tanaka, Masashi
Honda, Shuji
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-19
دولة النشر
مصر
عدد الصفحات
7
الملخص EN
Royal jelly (RJ) produced by honeybees has been reported to possess diverse health-beneficial properties and has been implicated to have a function in longevity across diverse species as well as honeybees.
10-Hydroxy-2-decenoic acid (10-HDA), the major lipid component of RJ produced by honeybees, was previously shown to increase the lifespan of Caenorhabditis elegans.
The objective of this study is to elucidate signaling pathways that are involved in the lifespan extension by 10-HDA.
10-HDA further extended the lifespan of the daf-2 mutants, which exhibit long lifespan through reducing insulin-like signaling (ILS), indicating that 10-HDA extended lifespan independently of ILS.
On the other hand, 10-HDA did not extend the lifespan of the eat-2 mutants, which show long lifespan through dietary restriction caused by a food-intake defect.
This finding indicates that 10-HDA extends lifespan through dietary restriction signaling.
We further found that 10-HDA did not extend the lifespan of the long-lived mutants in daf-15, which encodes Raptor, a target of rapamycin (TOR) components, indicating that 10-HDA shared some longevity control mechanisms with TOR signaling.
Additionally, 10-HDA was found to confer tolerance against thermal and oxidative stress.
10-HDA increases longevity not through ILS but through dietary restriction and TOR signaling in C.
elegans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Honda, Yoko& Araki, Yoko& Hata, Taketoshi& Ichihara, Kenji& Ito, Masafumi& Tanaka, Masashi…[et al.]. 2015. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling. Journal of Aging Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067270
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Honda, Yoko…[et al.]. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling. Journal of Aging Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067270
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Honda, Yoko& Araki, Yoko& Hata, Taketoshi& Ichihara, Kenji& Ito, Masafumi& Tanaka, Masashi…[et al.]. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling. Journal of Aging Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067270
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067270
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر