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An Open-Label Trial of Memantine for Cognitive Impairment in Patients with Posttraumatic Stress Disorder
المؤلفون المشاركون
Petty, F.
Ramaswamy, S.
Madabushi, Jayakrishna
Hunziker, John
Bhatia, Subhash C.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-12
دولة النشر
مصر
عدد الصفحات
6
الملخص EN
Background.
Studies using standard neuropsychological instruments have demonstrated memory deficits in patients with PTSD.
We evaluated the efficacy and safety of the N-methyl-D-aspartate antagonist memantine in veterans with PTSD and cognitive impairment.
Methods.
Twenty-six veterans with PTSD and cognitive impairment received 16 weeks of memantine in an open-label fashion.
Cognition was assessed using the Spatial Span, Logical Memory I, and Letter-Number Sequencing subtests of the Wechsler Memory Scale III and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).
RBANS measures attention, language, visuospatial skills, and immediate and delayed memories.
The Clinician Administered PTSD Scale (CAPS), Hamilton Depression Scale (HAM-D), Hamilton Anxiety Scale (HAM-A), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), and Sheehan Disability Scale (SDS) were secondary outcome measures.
Results.
There was a significant improvement in RBANS, both total and subscale scores (P<0.05), over time.
There was a reduction in total CAPS scores, avoidance/numbing symptoms (CAPS-C) and hyperarousal symptoms (CAPS-D), HAM-D, Q-LES-Q, and SDS scores.
However, there was no reduction in reexperiencing (CAPS-B) and HAM-A scores.
Memantine was well tolerated.
Conclusions.
Memantine improved cognitive symptoms, PTSD symptoms, and mood in veterans with PTSD.
Randomized double-blind studies are needed to validate these preliminary observations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ramaswamy, S.& Madabushi, Jayakrishna& Hunziker, John& Bhatia, Subhash C.& Petty, F.. 2015. An Open-Label Trial of Memantine for Cognitive Impairment in Patients with Posttraumatic Stress Disorder. Journal of Aging Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067280
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ramaswamy, S.…[et al.]. An Open-Label Trial of Memantine for Cognitive Impairment in Patients with Posttraumatic Stress Disorder. Journal of Aging Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1067280
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ramaswamy, S.& Madabushi, Jayakrishna& Hunziker, John& Bhatia, Subhash C.& Petty, F.. An Open-Label Trial of Memantine for Cognitive Impairment in Patients with Posttraumatic Stress Disorder. Journal of Aging Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067280
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067280
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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