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Synthesis, Characterization, and Pharmacological Evaluation of Selected Aromatic Amines
المؤلفون المشاركون
Ismail, Hammad
Mirza, Bushra
Haq, Ihsan-ul
Shabbir, Muhammad
Akhter, Zareen
Basharat, Amina
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aromatic amines 1-amino-4-phenoxybenzene (A-1A), 2-(4-aminophenoxy) naphthalene (A-2A), and 1-(4-aminophenoxy) naphthalene (A-3A) were synthesized by the reduction of corresponding nitroaromatics with hydrazine monohydrate and Pd/C 5% (w/w).
The newly synthesized compounds were characterized by FTIR, 1H NMR, 13C NMR, UV-visible spectrophotometer, and mass spectrometry and their biological activities were investigated along with structurally similar 4-(4-aminophenyloxy) biphenyl (A-A).
Results of brine shrimp cytotoxicity assay showed that almost all of the compounds had LD50 values <1 μg/mL.
The compounds also showed significant antitumor activity with IC50 values ranging from 67.45 to 12.2 µgmL−1.
The cytotoxicity and antitumor studies correlate the results which suggests the anticancerous nature of compounds.
During the interaction study of these compounds with DNA, all of the compounds showed hyperchromic effect indicating strong interaction through binding with the grooves of DNA.
Moreover, A-3A also showed decrease in λmax confirming higher propensity for DNA groove binding.
In DPPH free radical scavenging assay, all the compounds showed potential antioxidant capability.
The compounds were highly active in protecting DNA against hydroxyl free radicals.
DNA interaction and antioxidant results back up each other indicating that these compounds have potential to be used as cancer chemopreventive agents.
Additionally, one compound (A-1A) showed significant antibacterial and antifungal activity as well.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ismail, Hammad& Mirza, Bushra& Haq, Ihsan-ul& Shabbir, Muhammad& Akhter, Zareen& Basharat, Amina. 2015. Synthesis, Characterization, and Pharmacological Evaluation of Selected Aromatic Amines. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ismail, Hammad…[et al.]. Synthesis, Characterization, and Pharmacological Evaluation of Selected Aromatic Amines. Journal of Chemistry No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1067470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ismail, Hammad& Mirza, Bushra& Haq, Ihsan-ul& Shabbir, Muhammad& Akhter, Zareen& Basharat, Amina. Synthesis, Characterization, and Pharmacological Evaluation of Selected Aromatic Amines. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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